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Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study

Force generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted co...

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Autores principales: Braaß, Hanna, Feldheim, Jan, Chu, Ying, Tinnermann, Alexandra, Finsterbusch, Jürgen, Büchel, Christian, Schulz, Robert, Gerloff, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681651/
https://www.ncbi.nlm.nih.gov/pubmed/37873743
http://dx.doi.org/10.1002/hbm.26523
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author Braaß, Hanna
Feldheim, Jan
Chu, Ying
Tinnermann, Alexandra
Finsterbusch, Jürgen
Büchel, Christian
Schulz, Robert
Gerloff, Christian
author_facet Braaß, Hanna
Feldheim, Jan
Chu, Ying
Tinnermann, Alexandra
Finsterbusch, Jürgen
Büchel, Christian
Schulz, Robert
Gerloff, Christian
author_sort Braaß, Hanna
collection PubMed
description Force generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted combined cortico‐spinal functional magnetic resonance imaging during a simple visually guided isometric force generation task in 20 healthy young subjects. Activation was localized in the right cervical spinal cord and left primary motor and premotor areas. The main finding is that spinal activation was negatively correlated with ventral premotor cortex activation. Spinal activation was furthermore significantly correlated with primary motor cortex activation, while increasing target forces led to an increase in the amount of activation. These data indicate that human premotor areas such as the ventral premotor cortex might be functionally connected to the lower cervical spinal cord contributing to distal upper limb functions, a finding that extends our understanding of human motor function beyond the animal literature.
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spelling pubmed-106816512023-10-24 Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study Braaß, Hanna Feldheim, Jan Chu, Ying Tinnermann, Alexandra Finsterbusch, Jürgen Büchel, Christian Schulz, Robert Gerloff, Christian Hum Brain Mapp Research Articles Force generation is a crucial element of dexterity and a highly relevant skill of the human motor system. How cerebral and spinal components interact and how spinal activation is associated with the activity in the cerebral primary motor and premotor areas is poorly understood. Here, we conducted combined cortico‐spinal functional magnetic resonance imaging during a simple visually guided isometric force generation task in 20 healthy young subjects. Activation was localized in the right cervical spinal cord and left primary motor and premotor areas. The main finding is that spinal activation was negatively correlated with ventral premotor cortex activation. Spinal activation was furthermore significantly correlated with primary motor cortex activation, while increasing target forces led to an increase in the amount of activation. These data indicate that human premotor areas such as the ventral premotor cortex might be functionally connected to the lower cervical spinal cord contributing to distal upper limb functions, a finding that extends our understanding of human motor function beyond the animal literature. John Wiley & Sons, Inc. 2023-10-24 /pmc/articles/PMC10681651/ /pubmed/37873743 http://dx.doi.org/10.1002/hbm.26523 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Braaß, Hanna
Feldheim, Jan
Chu, Ying
Tinnermann, Alexandra
Finsterbusch, Jürgen
Büchel, Christian
Schulz, Robert
Gerloff, Christian
Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title_full Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title_fullStr Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title_full_unstemmed Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title_short Association between activity in the ventral premotor cortex and spinal cord activation during force generation—A combined cortico‐spinal fMRI study
title_sort association between activity in the ventral premotor cortex and spinal cord activation during force generation—a combined cortico‐spinal fmri study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681651/
https://www.ncbi.nlm.nih.gov/pubmed/37873743
http://dx.doi.org/10.1002/hbm.26523
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