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Regular cannabis use alters the neural dynamics serving complex motor control
Cannabis is the most widely used recreational drug in the United States and regular use has been linked to deficits in attention and memory. However, the effects of regular use on motor control are less understood, with some studies showing deficits and others indicating normal performance. Eighteen...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681654/ https://www.ncbi.nlm.nih.gov/pubmed/37955378 http://dx.doi.org/10.1002/hbm.26527 |
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author | Ward, Thomas W. Springer, Seth D. Schantell, Mikki John, Jason A. Horne, Lucy K. Coutant, Anna T. Okelberry, Hannah J. Willett, Madelyn P. Johnson, Hallie J. Killanin, Abraham D. Heinrichs‐Graham, Elizabeth Wilson, Tony W. |
author_facet | Ward, Thomas W. Springer, Seth D. Schantell, Mikki John, Jason A. Horne, Lucy K. Coutant, Anna T. Okelberry, Hannah J. Willett, Madelyn P. Johnson, Hallie J. Killanin, Abraham D. Heinrichs‐Graham, Elizabeth Wilson, Tony W. |
author_sort | Ward, Thomas W. |
collection | PubMed |
description | Cannabis is the most widely used recreational drug in the United States and regular use has been linked to deficits in attention and memory. However, the effects of regular use on motor control are less understood, with some studies showing deficits and others indicating normal performance. Eighteen users and 23 nonusers performed a motor sequencing task during high‐density magnetoencephalography (MEG). The MEG data was transformed into the time‐frequency domain and beta responses (16–24 Hz) during motor planning and execution phases were imaged separately using a beamformer approach. Whole‐brain maps were examined for group (cannabis user/nonuser) and time window (planning/execution) effects. As expected, there were no group differences in task performance (e.g., reaction time, accuracy, etc.). Regular cannabis users exhibited stronger beta oscillations in the contralateral primary motor cortex compared to nonusers during the execution phase of the motor sequences, but not during the motor planning phase. Similar group‐by‐time window interactions were observed in the left superior parietal, right inferior frontal cortices, right posterior insular cortex, and the bilateral motor cortex. We observed differences in the neural dynamics serving motor control in regular cannabis users compared to nonusers, suggesting regular users may employ compensatory processing in both primary motor and higher‐order motor cortices to maintain adequate task performance. Future studies will need to examine more complex motor control tasks to ascertain whether this putative compensatory activity eventually becomes exhausted and behavioral differences emerge. |
format | Online Article Text |
id | pubmed-10681654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106816542023-11-13 Regular cannabis use alters the neural dynamics serving complex motor control Ward, Thomas W. Springer, Seth D. Schantell, Mikki John, Jason A. Horne, Lucy K. Coutant, Anna T. Okelberry, Hannah J. Willett, Madelyn P. Johnson, Hallie J. Killanin, Abraham D. Heinrichs‐Graham, Elizabeth Wilson, Tony W. Hum Brain Mapp Research Articles Cannabis is the most widely used recreational drug in the United States and regular use has been linked to deficits in attention and memory. However, the effects of regular use on motor control are less understood, with some studies showing deficits and others indicating normal performance. Eighteen users and 23 nonusers performed a motor sequencing task during high‐density magnetoencephalography (MEG). The MEG data was transformed into the time‐frequency domain and beta responses (16–24 Hz) during motor planning and execution phases were imaged separately using a beamformer approach. Whole‐brain maps were examined for group (cannabis user/nonuser) and time window (planning/execution) effects. As expected, there were no group differences in task performance (e.g., reaction time, accuracy, etc.). Regular cannabis users exhibited stronger beta oscillations in the contralateral primary motor cortex compared to nonusers during the execution phase of the motor sequences, but not during the motor planning phase. Similar group‐by‐time window interactions were observed in the left superior parietal, right inferior frontal cortices, right posterior insular cortex, and the bilateral motor cortex. We observed differences in the neural dynamics serving motor control in regular cannabis users compared to nonusers, suggesting regular users may employ compensatory processing in both primary motor and higher‐order motor cortices to maintain adequate task performance. Future studies will need to examine more complex motor control tasks to ascertain whether this putative compensatory activity eventually becomes exhausted and behavioral differences emerge. John Wiley & Sons, Inc. 2023-11-13 /pmc/articles/PMC10681654/ /pubmed/37955378 http://dx.doi.org/10.1002/hbm.26527 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Ward, Thomas W. Springer, Seth D. Schantell, Mikki John, Jason A. Horne, Lucy K. Coutant, Anna T. Okelberry, Hannah J. Willett, Madelyn P. Johnson, Hallie J. Killanin, Abraham D. Heinrichs‐Graham, Elizabeth Wilson, Tony W. Regular cannabis use alters the neural dynamics serving complex motor control |
title | Regular cannabis use alters the neural dynamics serving complex motor control |
title_full | Regular cannabis use alters the neural dynamics serving complex motor control |
title_fullStr | Regular cannabis use alters the neural dynamics serving complex motor control |
title_full_unstemmed | Regular cannabis use alters the neural dynamics serving complex motor control |
title_short | Regular cannabis use alters the neural dynamics serving complex motor control |
title_sort | regular cannabis use alters the neural dynamics serving complex motor control |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681654/ https://www.ncbi.nlm.nih.gov/pubmed/37955378 http://dx.doi.org/10.1002/hbm.26527 |
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