Monitoring response to a clinically relevant IDH inhibitor in glioma—Hyperpolarized (13)C magnetic resonance spectroscopy approaches

BACKGROUND: Mutant isocitrate dehydrogenase (IDHmut) catalyzes 2-hydroxyglutarate (2HG) production and is considered a therapeutic target for IDHmut tumors. However, response is mostly associated with inhibition of tumor growth. Response assessment via anatomic imaging is therefore challenging. Our...

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Detalles Bibliográficos
Autores principales: Hong, Donghyun, Kim, Yaewon, Mushti, Chandrasekhar, Minami, Noriaki, Wu, Jing, Cherukuri, Murali Krishna, Swenson, Rolf E, Vigneron, Daniel B, Ronen, Sabrina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681661/
https://www.ncbi.nlm.nih.gov/pubmed/38024238
http://dx.doi.org/10.1093/noajnl/vdad143

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