Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response

Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene expression. Previously, we described widespread APA occurrence in introns during the DNA damage response (DDR). Here, we show that a DDR-activated APA event occurs in the first intron of CDKN1A, inducing an altern...

Descripción completa

Detalles Bibliográficos
Autores principales: Murphy, Michael R, Ramadei, Anthony, Doymaz, Ahmet, Varriano, Sophia, Natelson, Devorah M, Yu, Amy, Aktas, Sera, Mazzeo, Marie, Mazzeo, Michael, Zakusilo, George, Kleiman, Frida E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681730/
https://www.ncbi.nlm.nih.gov/pubmed/37870464
http://dx.doi.org/10.1093/nar/gkad899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681730/
https://www.ncbi.nlm.nih.gov/pubmed/37870464
http://dx.doi.org/10.1093/nar/gkad899

Ejemplares similares