ADAR1 links R-loop homeostasis to ATR activation in replication stress response

Unscheduled R-loops are a major source of replication stress and DNA damage. R-loop-induced replication defects are sensed and suppressed by ATR kinase, whereas it is not known whether R-loop itself is actively involved in ATR activation and, if so, how this is achieved. Here, we report that the nuc...

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Detalles Bibliográficos
Autores principales: Zhang, Biao, Li, Yi, Zhang, Jieyou, Wang, Yuejiao, Liang, Can, Lu, Ting, Zhang, Chunyong, Liu, Ling, Qin, Yan, He, Jiahuan, Zhao, Xiangnan, Yu, Jia, Hao, Jihui, Yang, Jie, Li, Mulin Jun, Yao, Zhi, Ma, Shuai, Cheng, Hui, Cheng, Tao, Shi, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681745/
https://www.ncbi.nlm.nih.gov/pubmed/37831098
http://dx.doi.org/10.1093/nar/gkad839

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