Cargando…

Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair

OBJECTIVES: The surgical treatment of coarctation of aorta with hypoplastic aortic arch (CoA/HAA) was challenging to achieve long-lasting arch patency. We reviewed early and late outcomes in our centre and identified predictors for arch reobstruction. METHODS: A retrospective analysis of medical rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Hui, Chengyi, Ren, Qiushi, Zhuang, Jian, Chen, Jimei, Li, Xiaohua, Cui, Hujun, Cen, Jianzheng, Xu, Gang, Wen, Shusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681811/
https://www.ncbi.nlm.nih.gov/pubmed/37991842
http://dx.doi.org/10.1093/icvts/ivad186
_version_ 1785150841330597888
author Hui, Chengyi
Ren, Qiushi
Zhuang, Jian
Chen, Jimei
Li, Xiaohua
Cui, Hujun
Cen, Jianzheng
Xu, Gang
Wen, Shusheng
author_facet Hui, Chengyi
Ren, Qiushi
Zhuang, Jian
Chen, Jimei
Li, Xiaohua
Cui, Hujun
Cen, Jianzheng
Xu, Gang
Wen, Shusheng
author_sort Hui, Chengyi
collection PubMed
description OBJECTIVES: The surgical treatment of coarctation of aorta with hypoplastic aortic arch (CoA/HAA) was challenging to achieve long-lasting arch patency. We reviewed early and late outcomes in our centre and identified predictors for arch reobstruction. METHODS: A retrospective analysis of medical records was performed to identify CoA/HAA patients who underwent primary arch reconstruction via median sternotomy between 2011 and 2020. Preoperative aortic arch geometry was analysed with cardiac computed tomographic angiography. Bedside flexible fibre-optic bronchoscopy was routinely performed after surgery in intensive care unit. RESULTS: There were 104 consecutive patients (median age 39.5 days) who underwent extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation. Early mortality was 3.8% and overall survival was 94.1% [95% confidence interval (CI) 89.6–98.8%] at 1, 3 and 5 years. Reobstruction-free survival was 85.1% (95% CI 78.4–92.3%) at 1 year, 80.6% (95% CI 73.1–88.9%) at 3 years and 77.4% (95% CI 69.2–86.6%) at 5 years. Preoperative aortic arch geometric parameters were not important factors for reobstruction. Nineteen patients (18.3%) were detected with left main bronchus compression (LMBC) on flexible fibre-optic bronchoscopy. Cardiopulmonary bypass time [P < 0.001, hazard ratio (95% CI): 1.02 (1.01–1.03)] and postoperative LMBC [P = 0.034, hazard ratio (95% CI): 2.99 (1.09–8.23)] were independent predictive factors on multivariable Cox regression analysis of reobstruction-free survival. CONCLUSIONS: Aortic arch can be satisfactorily repaired by extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation via median sternotomy in CoA/HAA. Cardiopulmonary bypass time and postoperative LMBC detected by flexible fibre-optic bronchoscopy are significant predictors for long-term arch reobstruction.
format Online
Article
Text
id pubmed-10681811
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-106818112023-11-22 Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair Hui, Chengyi Ren, Qiushi Zhuang, Jian Chen, Jimei Li, Xiaohua Cui, Hujun Cen, Jianzheng Xu, Gang Wen, Shusheng Interdiscip Cardiovasc Thorac Surg Congenital Disease OBJECTIVES: The surgical treatment of coarctation of aorta with hypoplastic aortic arch (CoA/HAA) was challenging to achieve long-lasting arch patency. We reviewed early and late outcomes in our centre and identified predictors for arch reobstruction. METHODS: A retrospective analysis of medical records was performed to identify CoA/HAA patients who underwent primary arch reconstruction via median sternotomy between 2011 and 2020. Preoperative aortic arch geometry was analysed with cardiac computed tomographic angiography. Bedside flexible fibre-optic bronchoscopy was routinely performed after surgery in intensive care unit. RESULTS: There were 104 consecutive patients (median age 39.5 days) who underwent extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation. Early mortality was 3.8% and overall survival was 94.1% [95% confidence interval (CI) 89.6–98.8%] at 1, 3 and 5 years. Reobstruction-free survival was 85.1% (95% CI 78.4–92.3%) at 1 year, 80.6% (95% CI 73.1–88.9%) at 3 years and 77.4% (95% CI 69.2–86.6%) at 5 years. Preoperative aortic arch geometric parameters were not important factors for reobstruction. Nineteen patients (18.3%) were detected with left main bronchus compression (LMBC) on flexible fibre-optic bronchoscopy. Cardiopulmonary bypass time [P < 0.001, hazard ratio (95% CI): 1.02 (1.01–1.03)] and postoperative LMBC [P = 0.034, hazard ratio (95% CI): 2.99 (1.09–8.23)] were independent predictive factors on multivariable Cox regression analysis of reobstruction-free survival. CONCLUSIONS: Aortic arch can be satisfactorily repaired by extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation via median sternotomy in CoA/HAA. Cardiopulmonary bypass time and postoperative LMBC detected by flexible fibre-optic bronchoscopy are significant predictors for long-term arch reobstruction. Oxford University Press 2023-11-22 /pmc/articles/PMC10681811/ /pubmed/37991842 http://dx.doi.org/10.1093/icvts/ivad186 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Congenital Disease
Hui, Chengyi
Ren, Qiushi
Zhuang, Jian
Chen, Jimei
Li, Xiaohua
Cui, Hujun
Cen, Jianzheng
Xu, Gang
Wen, Shusheng
Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title_full Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title_fullStr Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title_full_unstemmed Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title_short Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
title_sort bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair
topic Congenital Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681811/
https://www.ncbi.nlm.nih.gov/pubmed/37991842
http://dx.doi.org/10.1093/icvts/ivad186
work_keys_str_mv AT huichengyi bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT renqiushi bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT zhuangjian bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT chenjimei bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT lixiaohua bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT cuihujun bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT cenjianzheng bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT xugang bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair
AT wenshusheng bronchuscompressionisapredictorforreobstructionincoarctationwithhypoplasticarchrepair