E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation

S100A8/S100A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is unclear. Here, we show that E-selectin-induced rapid S100A8/S100A9 release during...

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Detalles Bibliográficos
Autores principales: Pruenster, Monika, Immler, Roland, Roth, Jonas, Kuchler, Tim, Bromberger, Thomas, Napoli, Matteo, Nussbaumer, Katrin, Rohwedder, Ina, Wackerbarth, Lou Martha, Piantoni, Chiara, Hennis, Konstantin, Fink, Diana, Kallabis, Sebastian, Schroll, Tobias, Masgrau-Alsina, Sergi, Budke, Agnes, Liu, Wang, Vestweber, Dietmar, Wahl-Schott, Christian, Roth, Johannes, Meissner, Felix, Moser, Markus, Vogl, Thomas, Hornung, Veit, Broz, Petr, Sperandio, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681899/
https://www.ncbi.nlm.nih.gov/pubmed/37903858
http://dx.doi.org/10.1038/s41590-023-01656-1

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