Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1

Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) differentiation into megakary...

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Detalles Bibliográficos
Autores principales: Zhou, Li, Wu, Dongxiao, Zhou, Yabo, Wang, Dianheng, Fu, Haixia, Huang, Qiusha, Qin, Guohui, Chen, Jie, Lv, Jiadi, Lai, Shaoyang, Zhang, Huafeng, Tang, Ke, Ma, Jingwei, Fiskesund, Roland, Zhang, Yi, Zhang, Xiaohui, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681900/
https://www.ncbi.nlm.nih.gov/pubmed/37919525
http://dx.doi.org/10.1038/s41590-023-01662-3

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