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Harnessing CD3 diversity to optimize CAR T cells

Current US Food and Drug Administration-approved chimeric antigen receptor (CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation domain in addition to costimulatory domains. The functionality in a CAR format of the other chains of the TCR complex, namely CD3δ,...

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Detalles Bibliográficos
Autores principales:	Velasco Cárdenas, Rubí M.-H., Brandl, Simon M., Meléndez, Ana Valeria, Schlaak, Alexandra Emilia, Buschky, Annabelle, Peters, Timo, Beier, Fabian, Serrels, Bryan, Taromi, Sanaz, Raute, Katrin, Hauri, Simon, Gstaiger, Matthias, Lassmann, Silke, Huppa, Johannes B., Boerries, Melanie, Andrieux, Geoffroy, Bengsch, Bertram, Schamel, Wolfgang W., Minguet, Susana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681901/ https://www.ncbi.nlm.nih.gov/pubmed/37932456 http://dx.doi.org/10.1038/s41590-023-01658-z

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