STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation

Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia (AML). These common hematopoietic disorders can be recapitulated in mouse models. However, the underlying mechanisms by wh...

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Detalles Bibliográficos
Autores principales: Xie, Jiaying, Sheng, Mengyao, Rong, Shaoqin, Zhou, Dan, Wang, Chao, Wu, Wanling, Huang, Jingru, Sun, Yue, Wang, Yin, Chen, Pingyue, Wu, Yushuang, Wang, Yuanxian, Wang, Lan, Zhou, Bo O., Huang, Xinxin, Walsh, Colum P., Bohlander, Stefan K., Huang, Jian, Wang, Xiaoqin, Xu, Guo-Liang, Gao, Hai, Shi, Yuheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681905/
https://www.ncbi.nlm.nih.gov/pubmed/37816954
http://dx.doi.org/10.1038/s41375-023-02055-z

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