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Inverse association between adult height and diabetes risk in a cohort study of Chinese population

Recent studies linking adult height to diabetes risk remain controversial and few were from Asia. This study, therefore, aimed to explore the association of adult height with diabetes risk in a Chinese population. This retrospective cohort study was a secondary analysis of data from the DATADRYAD we...

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Autores principales: Li, Xiaoli, Cheng, Tiantian, Leng, Lina, Song, Guangyao, Ma, Huijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681985/
https://www.ncbi.nlm.nih.gov/pubmed/38012198
http://dx.doi.org/10.1038/s41598-023-47474-1
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author Li, Xiaoli
Cheng, Tiantian
Leng, Lina
Song, Guangyao
Ma, Huijuan
author_facet Li, Xiaoli
Cheng, Tiantian
Leng, Lina
Song, Guangyao
Ma, Huijuan
author_sort Li, Xiaoli
collection PubMed
description Recent studies linking adult height to diabetes risk remain controversial and few were from Asia. This study, therefore, aimed to explore the association of adult height with diabetes risk in a Chinese population. This retrospective cohort study was a secondary analysis of data from the DATADRYAD website, involving 211,172 non-diabetic individuals aged ≥ 20 years from the health screening program in China. Cox regression models were employed to evaluate hazard ratios (HRs) with 95% confidence interval (CI) of diabetes related to height. During an average 3.12-year follow-up, 4156 (1.97%) subjects reported developing diabetes. After adjusting for potential confounding factors, an inverse association of height with diabetes risk was observed among men and women [HR per 10 cm (95% CI), 0.78 (0.73–0.83) and 0.76 (0.68–0.86), respectively]. Moreover, subgroup analyses indicated the inverse association was only detected in individuals with aged < 70 years, fasting plasma glucose (FPG) < 6.1 mmol/L, and men with body mass index (BMI) < 28 kg/m(2). In brief, height is inversely associated with diabetes risk in Chinese adults. Specifically, this association appears to be more pronounced in individuals with aged < 70 years, FPG < 6.1 mmol/L, and men with BMI < 28 kg/m(2).
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spelling pubmed-106819852023-11-30 Inverse association between adult height and diabetes risk in a cohort study of Chinese population Li, Xiaoli Cheng, Tiantian Leng, Lina Song, Guangyao Ma, Huijuan Sci Rep Article Recent studies linking adult height to diabetes risk remain controversial and few were from Asia. This study, therefore, aimed to explore the association of adult height with diabetes risk in a Chinese population. This retrospective cohort study was a secondary analysis of data from the DATADRYAD website, involving 211,172 non-diabetic individuals aged ≥ 20 years from the health screening program in China. Cox regression models were employed to evaluate hazard ratios (HRs) with 95% confidence interval (CI) of diabetes related to height. During an average 3.12-year follow-up, 4156 (1.97%) subjects reported developing diabetes. After adjusting for potential confounding factors, an inverse association of height with diabetes risk was observed among men and women [HR per 10 cm (95% CI), 0.78 (0.73–0.83) and 0.76 (0.68–0.86), respectively]. Moreover, subgroup analyses indicated the inverse association was only detected in individuals with aged < 70 years, fasting plasma glucose (FPG) < 6.1 mmol/L, and men with body mass index (BMI) < 28 kg/m(2). In brief, height is inversely associated with diabetes risk in Chinese adults. Specifically, this association appears to be more pronounced in individuals with aged < 70 years, FPG < 6.1 mmol/L, and men with BMI < 28 kg/m(2). Nature Publishing Group UK 2023-11-27 /pmc/articles/PMC10681985/ /pubmed/38012198 http://dx.doi.org/10.1038/s41598-023-47474-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Xiaoli
Cheng, Tiantian
Leng, Lina
Song, Guangyao
Ma, Huijuan
Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title_full Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title_fullStr Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title_full_unstemmed Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title_short Inverse association between adult height and diabetes risk in a cohort study of Chinese population
title_sort inverse association between adult height and diabetes risk in a cohort study of chinese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681985/
https://www.ncbi.nlm.nih.gov/pubmed/38012198
http://dx.doi.org/10.1038/s41598-023-47474-1
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