SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm

SRSF2 mutations are found in association with JAK2V617F in myeloproliferative neoplasms (MPN), most frequently in myelofibrosis (MF). However, the contribution of SRSF2 mutation in JAK2V617F-driven MPN remains elusive. To investigate the consequences of SRSF2(P95H) and JAK2(V617F) mutations in MPN,...

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Detalles Bibliográficos
Autores principales: Yang, Yue, Abbas, Salar, Sayem, Mohammad A., Dutta, Avik, Mohi, Golam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682023/
https://www.ncbi.nlm.nih.gov/pubmed/38012156
http://dx.doi.org/10.1038/s41408-023-00947-y

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