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Targeting the lactic acid metabolic pathway for antitumor therapy
Lactic acid is one of the most abundant products of cellular metabolism and has historically been considered a cell-damaging metabolic product. However, as research has deepened, the beneficial effects of lactic acid on tumor cells and the tumor microenvironment have received increasing attention fr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682057/ https://www.ncbi.nlm.nih.gov/pubmed/38033399 http://dx.doi.org/10.1016/j.omto.2023.100740 |
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author | Li, Zhi Cui, Jiuwei |
author_facet | Li, Zhi Cui, Jiuwei |
author_sort | Li, Zhi |
collection | PubMed |
description | Lactic acid is one of the most abundant products of cellular metabolism and has historically been considered a cell-damaging metabolic product. However, as research has deepened, the beneficial effects of lactic acid on tumor cells and the tumor microenvironment have received increasing attention from the oncology community. Lactic acid can not only provide tumor cells with energy but also act as a messenger molecule that promotes tumor growth and progression and protects tumor cells from immune cells and killing by radiation and chemotherapy. Thus, the inhibition of tumor cell lactic acid metabolism has emerged as a novel antitumor treatment strategy that can also effectively enhance the efficacy of conventional antitumor therapies. In this review, we classify the currently available therapies targeting lactic acid metabolism and examine their prospects for clinical application. |
format | Online Article Text |
id | pubmed-10682057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-106820572023-11-30 Targeting the lactic acid metabolic pathway for antitumor therapy Li, Zhi Cui, Jiuwei Mol Ther Oncolytics Review Lactic acid is one of the most abundant products of cellular metabolism and has historically been considered a cell-damaging metabolic product. However, as research has deepened, the beneficial effects of lactic acid on tumor cells and the tumor microenvironment have received increasing attention from the oncology community. Lactic acid can not only provide tumor cells with energy but also act as a messenger molecule that promotes tumor growth and progression and protects tumor cells from immune cells and killing by radiation and chemotherapy. Thus, the inhibition of tumor cell lactic acid metabolism has emerged as a novel antitumor treatment strategy that can also effectively enhance the efficacy of conventional antitumor therapies. In this review, we classify the currently available therapies targeting lactic acid metabolism and examine their prospects for clinical application. American Society of Gene & Cell Therapy 2023-10-31 /pmc/articles/PMC10682057/ /pubmed/38033399 http://dx.doi.org/10.1016/j.omto.2023.100740 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Li, Zhi Cui, Jiuwei Targeting the lactic acid metabolic pathway for antitumor therapy |
title | Targeting the lactic acid metabolic pathway for antitumor therapy |
title_full | Targeting the lactic acid metabolic pathway for antitumor therapy |
title_fullStr | Targeting the lactic acid metabolic pathway for antitumor therapy |
title_full_unstemmed | Targeting the lactic acid metabolic pathway for antitumor therapy |
title_short | Targeting the lactic acid metabolic pathway for antitumor therapy |
title_sort | targeting the lactic acid metabolic pathway for antitumor therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682057/ https://www.ncbi.nlm.nih.gov/pubmed/38033399 http://dx.doi.org/10.1016/j.omto.2023.100740 |
work_keys_str_mv | AT lizhi targetingthelacticacidmetabolicpathwayforantitumortherapy AT cuijiuwei targetingthelacticacidmetabolicpathwayforantitumortherapy |