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Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China

Antenatal exposure to air pollutants is thought to be associated with a variety of maternal blood markers as well as adverse birth outcomes. However, the dysgenic influence of air pollutants on the antiphospholipid syndrome (APS) in mothers and their pregnancy outcomes remains unclear. In the curren...

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Autores principales: Hu, Bimei, Xu, Linjie, Yang, Xu, Qu, Shiwen, Wu, Lan, Sun, Yumei, Yan, Jun, Zhang, Yexiao, Yu, Zhaoer, Wang, Yixiao, Jia, Ruizhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682106/
https://www.ncbi.nlm.nih.gov/pubmed/37910359
http://dx.doi.org/10.1007/s11356-023-29937-0
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author Hu, Bimei
Xu, Linjie
Yang, Xu
Qu, Shiwen
Wu, Lan
Sun, Yumei
Yan, Jun
Zhang, Yexiao
Yu, Zhaoer
Wang, Yixiao
Jia, Ruizhe
author_facet Hu, Bimei
Xu, Linjie
Yang, Xu
Qu, Shiwen
Wu, Lan
Sun, Yumei
Yan, Jun
Zhang, Yexiao
Yu, Zhaoer
Wang, Yixiao
Jia, Ruizhe
author_sort Hu, Bimei
collection PubMed
description Antenatal exposure to air pollutants is thought to be associated with a variety of maternal blood markers as well as adverse birth outcomes. However, the dysgenic influence of air pollutants on the antiphospholipid syndrome (APS) in mothers and their pregnancy outcomes remains unclear. In the current study, 371 mother-infant pairs (189 healthy: 182 APS) from Nanjing Maternal and Child Health Hospital as well as air pollutants concentration from their living environment were used to investigate correlations between air pollution with maternal blood indicators and fetal birth weight in the groups of APS and healthy mothers. Generalized linear model was used to evaluate the contributions of air pollutant exposure during pregnancy to the blood indicators variation. The relationships between birth weight with specific air pollutant and blood index were analyzed using ridge regression. Results showed that APS fetal birth weight was significantly impacted by air pollutant exposure during pregnancy, in particular, the birth weight decreased significantly along with increasing fine particulate matter 2.5 (PM(2.5)) and fine particulate matter 10 (PM(10)) exposure concentrations throughout pregnancy. In contrast, birth weight increased significantly with sulfur dioxide (SO(2)) exposure. In addition, APS-related blood indicators comprised of platelet distribution width (PDW), total bilirubin (TBIL), mean platelet volume (MPV), platelet-larger cell ratio (P_LCR), homocysteine (HCY), alkaline phosphatase (ALP), direct bilirubin (DBIL), basophilic granulocyte (BAS), platelet thrombocytocrit (PCT), preprandial glucose levels (OGTT0), monocytes (MON), and monocytes ratio (MON_ratio) were also strongly related with prenatal exposure to PM(2.5) and PM(10), in which PDW levels showed most strongly negative impaction on fetal birth weight. Together, we showed that prenatal exposure to air pollutant (PM(2.5) and PM(10)) may exacerbate the poor birth outcomes of low birth weight by impacting APS maternal blood indicators especially for PDW. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-29937-0.
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spelling pubmed-106821062023-11-30 Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China Hu, Bimei Xu, Linjie Yang, Xu Qu, Shiwen Wu, Lan Sun, Yumei Yan, Jun Zhang, Yexiao Yu, Zhaoer Wang, Yixiao Jia, Ruizhe Environ Sci Pollut Res Int Research Article Antenatal exposure to air pollutants is thought to be associated with a variety of maternal blood markers as well as adverse birth outcomes. However, the dysgenic influence of air pollutants on the antiphospholipid syndrome (APS) in mothers and their pregnancy outcomes remains unclear. In the current study, 371 mother-infant pairs (189 healthy: 182 APS) from Nanjing Maternal and Child Health Hospital as well as air pollutants concentration from their living environment were used to investigate correlations between air pollution with maternal blood indicators and fetal birth weight in the groups of APS and healthy mothers. Generalized linear model was used to evaluate the contributions of air pollutant exposure during pregnancy to the blood indicators variation. The relationships between birth weight with specific air pollutant and blood index were analyzed using ridge regression. Results showed that APS fetal birth weight was significantly impacted by air pollutant exposure during pregnancy, in particular, the birth weight decreased significantly along with increasing fine particulate matter 2.5 (PM(2.5)) and fine particulate matter 10 (PM(10)) exposure concentrations throughout pregnancy. In contrast, birth weight increased significantly with sulfur dioxide (SO(2)) exposure. In addition, APS-related blood indicators comprised of platelet distribution width (PDW), total bilirubin (TBIL), mean platelet volume (MPV), platelet-larger cell ratio (P_LCR), homocysteine (HCY), alkaline phosphatase (ALP), direct bilirubin (DBIL), basophilic granulocyte (BAS), platelet thrombocytocrit (PCT), preprandial glucose levels (OGTT0), monocytes (MON), and monocytes ratio (MON_ratio) were also strongly related with prenatal exposure to PM(2.5) and PM(10), in which PDW levels showed most strongly negative impaction on fetal birth weight. Together, we showed that prenatal exposure to air pollutant (PM(2.5) and PM(10)) may exacerbate the poor birth outcomes of low birth weight by impacting APS maternal blood indicators especially for PDW. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-29937-0. Springer Berlin Heidelberg 2023-11-01 2023 /pmc/articles/PMC10682106/ /pubmed/37910359 http://dx.doi.org/10.1007/s11356-023-29937-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Hu, Bimei
Xu, Linjie
Yang, Xu
Qu, Shiwen
Wu, Lan
Sun, Yumei
Yan, Jun
Zhang, Yexiao
Yu, Zhaoer
Wang, Yixiao
Jia, Ruizhe
Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title_full Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title_fullStr Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title_full_unstemmed Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title_short Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China
title_sort association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in nanjing, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682106/
https://www.ncbi.nlm.nih.gov/pubmed/37910359
http://dx.doi.org/10.1007/s11356-023-29937-0
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