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Progress in the application of graphene and its derivatives to osteogenesis

As bone and joint injuries from various causes become increasingly prominent, how to effectively reconstruct and repair bone defects presents a difficult problem for clinicians and researchers. In recent years, graphene and its derivatives have been the subject of growing body of research and have b...

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Detalles Bibliográficos
Autores principales: Guo, Jianbin, Cao, Guihua, Wei, Song, Han, Yisheng, Xu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682167/
https://www.ncbi.nlm.nih.gov/pubmed/38034743
http://dx.doi.org/10.1016/j.heliyon.2023.e21872
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author Guo, Jianbin
Cao, Guihua
Wei, Song
Han, Yisheng
Xu, Peng
author_facet Guo, Jianbin
Cao, Guihua
Wei, Song
Han, Yisheng
Xu, Peng
author_sort Guo, Jianbin
collection PubMed
description As bone and joint injuries from various causes become increasingly prominent, how to effectively reconstruct and repair bone defects presents a difficult problem for clinicians and researchers. In recent years, graphene and its derivatives have been the subject of growing body of research and have been found to promote the proliferation and osteogenic differentiation of stem cells. This provides a new idea for solving the clinical problem of bone defects. However, as as numerous articles address various aspects and have not been fully systematized, there is an urgent need to classify and summarize them. In this paper, for the first time, the effects of graphene and its derivatives on stem cells in solution, in 2D and 3D structures and in vivo and their possible mechanisms are reviewed, and the cytotoxic effects of graphene and its derivatives were summarized and analyzed. The toxicity of graphene and its derivatives is further reviewed. In addition, we suggest possible future development directions of graphene and its derivatives in bone tissue engineering applications to provide a reference for further clinical application.
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spelling pubmed-106821672023-11-30 Progress in the application of graphene and its derivatives to osteogenesis Guo, Jianbin Cao, Guihua Wei, Song Han, Yisheng Xu, Peng Heliyon Review Article As bone and joint injuries from various causes become increasingly prominent, how to effectively reconstruct and repair bone defects presents a difficult problem for clinicians and researchers. In recent years, graphene and its derivatives have been the subject of growing body of research and have been found to promote the proliferation and osteogenic differentiation of stem cells. This provides a new idea for solving the clinical problem of bone defects. However, as as numerous articles address various aspects and have not been fully systematized, there is an urgent need to classify and summarize them. In this paper, for the first time, the effects of graphene and its derivatives on stem cells in solution, in 2D and 3D structures and in vivo and their possible mechanisms are reviewed, and the cytotoxic effects of graphene and its derivatives were summarized and analyzed. The toxicity of graphene and its derivatives is further reviewed. In addition, we suggest possible future development directions of graphene and its derivatives in bone tissue engineering applications to provide a reference for further clinical application. Elsevier 2023-11-08 /pmc/articles/PMC10682167/ /pubmed/38034743 http://dx.doi.org/10.1016/j.heliyon.2023.e21872 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Guo, Jianbin
Cao, Guihua
Wei, Song
Han, Yisheng
Xu, Peng
Progress in the application of graphene and its derivatives to osteogenesis
title Progress in the application of graphene and its derivatives to osteogenesis
title_full Progress in the application of graphene and its derivatives to osteogenesis
title_fullStr Progress in the application of graphene and its derivatives to osteogenesis
title_full_unstemmed Progress in the application of graphene and its derivatives to osteogenesis
title_short Progress in the application of graphene and its derivatives to osteogenesis
title_sort progress in the application of graphene and its derivatives to osteogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682167/
https://www.ncbi.nlm.nih.gov/pubmed/38034743
http://dx.doi.org/10.1016/j.heliyon.2023.e21872
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