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Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood

Adults typically exhibit right hemispheric dominance in the processing of faces. In this cross-sectional study, we investigated age-dependent changes in face processing lateralization from infancy to adulthood (1–48 years old; N = 194). We co-registered anatomical and resting state functional Magnet...

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Autores principales: Lesinger, Keren, Rosenthal, Gideon, Pierce, Karen, Courchesne, Eric, Dinstein, Ilan, Avidan, Galia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682179/
https://www.ncbi.nlm.nih.gov/pubmed/38012206
http://dx.doi.org/10.1038/s41598-023-47581-z
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author Lesinger, Keren
Rosenthal, Gideon
Pierce, Karen
Courchesne, Eric
Dinstein, Ilan
Avidan, Galia
author_facet Lesinger, Keren
Rosenthal, Gideon
Pierce, Karen
Courchesne, Eric
Dinstein, Ilan
Avidan, Galia
author_sort Lesinger, Keren
collection PubMed
description Adults typically exhibit right hemispheric dominance in the processing of faces. In this cross-sectional study, we investigated age-dependent changes in face processing lateralization from infancy to adulthood (1–48 years old; N = 194). We co-registered anatomical and resting state functional Magnetic Resonance Imaging (fMRI) scans of toddlers, children, adolescents, and adults into a common space and examined functional connectivity across the face, as well as place, and object-selective regions identified in adults. As expected, functional connectivity between core face-selective regions was stronger in the right compared to the left hemisphere in adults. Most importantly, the same lateralization was evident in all other age groups (infants, children, adolescents) and appeared only in face-selective regions, and not in place or object-selective regions. These findings suggest that the physiological development of face-selective brain areas may differ from that of object and place-selective areas. Specifically, the functional connectivity of the core-face selective regions exhibits rightward lateralization from infancy, years before these areas develop mature face-selective responses.
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spelling pubmed-106821792023-11-30 Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood Lesinger, Keren Rosenthal, Gideon Pierce, Karen Courchesne, Eric Dinstein, Ilan Avidan, Galia Sci Rep Article Adults typically exhibit right hemispheric dominance in the processing of faces. In this cross-sectional study, we investigated age-dependent changes in face processing lateralization from infancy to adulthood (1–48 years old; N = 194). We co-registered anatomical and resting state functional Magnetic Resonance Imaging (fMRI) scans of toddlers, children, adolescents, and adults into a common space and examined functional connectivity across the face, as well as place, and object-selective regions identified in adults. As expected, functional connectivity between core face-selective regions was stronger in the right compared to the left hemisphere in adults. Most importantly, the same lateralization was evident in all other age groups (infants, children, adolescents) and appeared only in face-selective regions, and not in place or object-selective regions. These findings suggest that the physiological development of face-selective brain areas may differ from that of object and place-selective areas. Specifically, the functional connectivity of the core-face selective regions exhibits rightward lateralization from infancy, years before these areas develop mature face-selective responses. Nature Publishing Group UK 2023-11-27 /pmc/articles/PMC10682179/ /pubmed/38012206 http://dx.doi.org/10.1038/s41598-023-47581-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lesinger, Keren
Rosenthal, Gideon
Pierce, Karen
Courchesne, Eric
Dinstein, Ilan
Avidan, Galia
Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title_full Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title_fullStr Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title_full_unstemmed Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title_short Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
title_sort functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682179/
https://www.ncbi.nlm.nih.gov/pubmed/38012206
http://dx.doi.org/10.1038/s41598-023-47581-z
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