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Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways

Flavonoids are a highly abundant class of secondary metabolites present in plants. Isoflavonoids, in particular, are primarily synthesized in leguminous plants within the subfamily Papilionoideae. Numerous reports have established the favorable role of isoflavonoids in preventing a range of human di...

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Autores principales: Yue, Zhiyong, He, Shanhong, Wang, Jinpei, Jiang, Qi, Wang, Hanping, Wu, Jia, Li, Chenxi, Wang, Zixian, He, Xuan, Jia, Nannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682181/
https://www.ncbi.nlm.nih.gov/pubmed/38034638
http://dx.doi.org/10.1016/j.heliyon.2023.e21874
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author Yue, Zhiyong
He, Shanhong
Wang, Jinpei
Jiang, Qi
Wang, Hanping
Wu, Jia
Li, Chenxi
Wang, Zixian
He, Xuan
Jia, Nannan
author_facet Yue, Zhiyong
He, Shanhong
Wang, Jinpei
Jiang, Qi
Wang, Hanping
Wu, Jia
Li, Chenxi
Wang, Zixian
He, Xuan
Jia, Nannan
author_sort Yue, Zhiyong
collection PubMed
description Flavonoids are a highly abundant class of secondary metabolites present in plants. Isoflavonoids, in particular, are primarily synthesized in leguminous plants within the subfamily Papilionoideae. Numerous reports have established the favorable role of isoflavonoids in preventing a range of human diseases. Among the isoflavonoid components, glyceollins are synthesized specifically in soybean plants and have displayed promising effects in mitigating the occurrence and progression of breast and ovarian cancers as well as other diseases. Consequently, glyceollins have become a sought-after natural component for promoting women's health. In recent years, extensive research has focused on investigating the molecular mechanism underlying the preventative properties of glyceollins against various diseases. Substantial progress has also been made toward elucidating the biosynthetic pathway of glyceollins and exploring potential regulatory factors. Herein, we provide a review of the research conducted on glyceollins since their discovery five decades ago (1972–2023). We summarize their pharmacological effects, biosynthetic pathways, and advancements in chemical synthesis to enhance our understanding of the molecular mechanisms of their function and the genes involved in their biosynthetic pathway. Such knowledge may facilitate improved glyceollin synthesis and the creation of health products based on glyceollins.
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spelling pubmed-106821812023-11-30 Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways Yue, Zhiyong He, Shanhong Wang, Jinpei Jiang, Qi Wang, Hanping Wu, Jia Li, Chenxi Wang, Zixian He, Xuan Jia, Nannan Heliyon Review Article Flavonoids are a highly abundant class of secondary metabolites present in plants. Isoflavonoids, in particular, are primarily synthesized in leguminous plants within the subfamily Papilionoideae. Numerous reports have established the favorable role of isoflavonoids in preventing a range of human diseases. Among the isoflavonoid components, glyceollins are synthesized specifically in soybean plants and have displayed promising effects in mitigating the occurrence and progression of breast and ovarian cancers as well as other diseases. Consequently, glyceollins have become a sought-after natural component for promoting women's health. In recent years, extensive research has focused on investigating the molecular mechanism underlying the preventative properties of glyceollins against various diseases. Substantial progress has also been made toward elucidating the biosynthetic pathway of glyceollins and exploring potential regulatory factors. Herein, we provide a review of the research conducted on glyceollins since their discovery five decades ago (1972–2023). We summarize their pharmacological effects, biosynthetic pathways, and advancements in chemical synthesis to enhance our understanding of the molecular mechanisms of their function and the genes involved in their biosynthetic pathway. Such knowledge may facilitate improved glyceollin synthesis and the creation of health products based on glyceollins. Elsevier 2023-11-04 /pmc/articles/PMC10682181/ /pubmed/38034638 http://dx.doi.org/10.1016/j.heliyon.2023.e21874 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Yue, Zhiyong
He, Shanhong
Wang, Jinpei
Jiang, Qi
Wang, Hanping
Wu, Jia
Li, Chenxi
Wang, Zixian
He, Xuan
Jia, Nannan
Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title_full Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title_fullStr Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title_full_unstemmed Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title_short Glyceollins from soybean: Their pharmacological effects and biosynthetic pathways
title_sort glyceollins from soybean: their pharmacological effects and biosynthetic pathways
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682181/
https://www.ncbi.nlm.nih.gov/pubmed/38034638
http://dx.doi.org/10.1016/j.heliyon.2023.e21874
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