The solution structure of the heavy chain–only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions

Heavy chain–only antibodies can offer advantages of higher binding affinities, reduced sizes, and higher stabilities than conventional antibodies. To address the challenge of SARS-CoV-2 coronavirus, a llama-derived single-domain nanobody C5 was developed previously that has high COVID-19 virus neutr...

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Detalles Bibliográficos
Autores principales: Gao, Xin, Thrush, Joseph W., Gor, Jayesh, Naismith, James H., Owens, Raymond J., Perkins, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682267/
https://www.ncbi.nlm.nih.gov/pubmed/37838175
http://dx.doi.org/10.1016/j.jbc.2023.105337

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