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The secreted peptide BATSP1 promotes thermogenesis in adipocytes
Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating factors in BAT that play a key role in controlling systemic energy homeostasis remain large...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682272/ https://www.ncbi.nlm.nih.gov/pubmed/38010450 http://dx.doi.org/10.1007/s00018-023-05027-9 |
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author | Cui, Xianwei Zhong, Hong Wu, Yangyang Zhang, Zhuo Zhang, Xiaoxiao Li, Lu He, Jin Chen, Chen Wu, Zhenggang Ji, Chenbo |
author_facet | Cui, Xianwei Zhong, Hong Wu, Yangyang Zhang, Zhuo Zhang, Xiaoxiao Li, Lu He, Jin Chen, Chen Wu, Zhenggang Ji, Chenbo |
author_sort | Cui, Xianwei |
collection | PubMed |
description | Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating factors in BAT that play a key role in controlling systemic energy homeostasis remain largely unexplored. Here, we performed a peptidomic analysis to profile the extracellular peptides released from human brown adipocytes upon exposure to thermogenic stimuli. Specifically, we identified a secreted peptide that modulates adipocyte thermogenesis in a cell-autonomous manner, and we named it BATSP1. BATSP1 promoted BAT thermogenesis and induced browning of white adipose tissue in vivo, leading to increased energy expenditure under cold stress. BATSP1 treatment in mice prevented high-fat diet-induced obesity and improved glucose tolerance and insulin resistance. Mechanistically, BATSP1 facilitated the nucleocytoplasmic shuttling of forkhead transcription factor 1 (FOXO1) and released its transcriptional inhibition of uncoupling protein 1 (UCP1). Overall, we provide a comprehensive analysis of the human brown adipocyte extracellular peptidome following acute forskolin (FSK) stimulation and identify BATSP1 as a novel regulator of thermogenesis that may offer a potential approach for obesity treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-023-05027-9. |
format | Online Article Text |
id | pubmed-10682272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-106822722023-11-30 The secreted peptide BATSP1 promotes thermogenesis in adipocytes Cui, Xianwei Zhong, Hong Wu, Yangyang Zhang, Zhuo Zhang, Xiaoxiao Li, Lu He, Jin Chen, Chen Wu, Zhenggang Ji, Chenbo Cell Mol Life Sci Original Article Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating factors in BAT that play a key role in controlling systemic energy homeostasis remain largely unexplored. Here, we performed a peptidomic analysis to profile the extracellular peptides released from human brown adipocytes upon exposure to thermogenic stimuli. Specifically, we identified a secreted peptide that modulates adipocyte thermogenesis in a cell-autonomous manner, and we named it BATSP1. BATSP1 promoted BAT thermogenesis and induced browning of white adipose tissue in vivo, leading to increased energy expenditure under cold stress. BATSP1 treatment in mice prevented high-fat diet-induced obesity and improved glucose tolerance and insulin resistance. Mechanistically, BATSP1 facilitated the nucleocytoplasmic shuttling of forkhead transcription factor 1 (FOXO1) and released its transcriptional inhibition of uncoupling protein 1 (UCP1). Overall, we provide a comprehensive analysis of the human brown adipocyte extracellular peptidome following acute forskolin (FSK) stimulation and identify BATSP1 as a novel regulator of thermogenesis that may offer a potential approach for obesity treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-023-05027-9. Springer International Publishing 2023-11-27 2023 /pmc/articles/PMC10682272/ /pubmed/38010450 http://dx.doi.org/10.1007/s00018-023-05027-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Cui, Xianwei Zhong, Hong Wu, Yangyang Zhang, Zhuo Zhang, Xiaoxiao Li, Lu He, Jin Chen, Chen Wu, Zhenggang Ji, Chenbo The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title | The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title_full | The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title_fullStr | The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title_full_unstemmed | The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title_short | The secreted peptide BATSP1 promotes thermogenesis in adipocytes |
title_sort | secreted peptide batsp1 promotes thermogenesis in adipocytes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682272/ https://www.ncbi.nlm.nih.gov/pubmed/38010450 http://dx.doi.org/10.1007/s00018-023-05027-9 |
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