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Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue
Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dia...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682454/ https://www.ncbi.nlm.nih.gov/pubmed/38012135 http://dx.doi.org/10.1038/s41467-023-43254-7 |
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author | Chang, HaoRan Esteves, Ingrid M. Neumann, Adam R. Mohajerani, Majid H. McNaughton, Bruce L. |
author_facet | Chang, HaoRan Esteves, Ingrid M. Neumann, Adam R. Mohajerani, Majid H. McNaughton, Bruce L. |
author_sort | Chang, HaoRan |
collection | PubMed |
description | Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca(2+) imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes from previous explorations in a virtual environment. We show that, following navigation, spontaneous resting state reactivations convey varying degrees of spatial (trajectory sequences) and non-spatial (visuo-tactile attributes) information, while reactivations of non-spatial attributes tend to precede reactivations of spatial representations surrounding hippocampal sharp-wave ripples. |
format | Online Article Text |
id | pubmed-10682454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106824542023-11-30 Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue Chang, HaoRan Esteves, Ingrid M. Neumann, Adam R. Mohajerani, Majid H. McNaughton, Bruce L. Nat Commun Article Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca(2+) imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes from previous explorations in a virtual environment. We show that, following navigation, spontaneous resting state reactivations convey varying degrees of spatial (trajectory sequences) and non-spatial (visuo-tactile attributes) information, while reactivations of non-spatial attributes tend to precede reactivations of spatial representations surrounding hippocampal sharp-wave ripples. Nature Publishing Group UK 2023-11-27 /pmc/articles/PMC10682454/ /pubmed/38012135 http://dx.doi.org/10.1038/s41467-023-43254-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chang, HaoRan Esteves, Ingrid M. Neumann, Adam R. Mohajerani, Majid H. McNaughton, Bruce L. Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title | Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title_full | Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title_fullStr | Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title_full_unstemmed | Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title_short | Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
title_sort | cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682454/ https://www.ncbi.nlm.nih.gov/pubmed/38012135 http://dx.doi.org/10.1038/s41467-023-43254-7 |
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