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Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage
Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such as those associated with lung edema. mRNAs formula...
Autores principales: | Radloff, Katrin, Gutbier, Birgitt, Dunne, Charlotte Maeve, Moradian, Hanieh, Schwestka, Marko, Gossen, Manfred, Ahrens, Katharina, Kneller, Laura, Wang, Yadong, Moga, Akanksha, Gkionis, Leonidas, Keil, Oliver, Fehring, Volker, Tondera, Daniel, Giese, Klaus, Santel, Ansgar, Kaufmann, Jörg, Witzenrath, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682670/ https://www.ncbi.nlm.nih.gov/pubmed/38034031 http://dx.doi.org/10.1016/j.omtn.2023.102068 |
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