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Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angio...

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Detalles Bibliográficos
Autores principales: Shao, Shengwen, Miao, Huilai, Ma, Wenxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682717/
https://www.ncbi.nlm.nih.gov/pubmed/38035068
http://dx.doi.org/10.3389/fimmu.2023.1295684
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author Shao, Shengwen
Miao, Huilai
Ma, Wenxue
author_facet Shao, Shengwen
Miao, Huilai
Ma, Wenxue
author_sort Shao, Shengwen
collection PubMed
description Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While substantial research has explored the fundamentals of TAMs, comprehending their adaptive behavior, and leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, and the complex orchestration of cytokines and chemokines determining their functions. We highlight the complexities of TAM-targeted research focusing on their adaptability and potential variability in therapeutic outcomes. Moreover, we discuss the synergy of integrating TAM-focused strategies with established cancer treatments, such as chemotherapy, and immunotherapy. Emphasis is laid on pioneering methods like TAM reprogramming for cancer immunotherapy and the adoption of single-cell technologies for precision intervention. This synthesis seeks to shed light on TAMs’ multifaceted roles in cancer, pinpointing prospective pathways for transformative research and enhancing therapeutic modalities in oncology.
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spelling pubmed-106827172023-11-30 Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs Shao, Shengwen Miao, Huilai Ma, Wenxue Front Immunol Immunology Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While substantial research has explored the fundamentals of TAMs, comprehending their adaptive behavior, and leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, and the complex orchestration of cytokines and chemokines determining their functions. We highlight the complexities of TAM-targeted research focusing on their adaptability and potential variability in therapeutic outcomes. Moreover, we discuss the synergy of integrating TAM-focused strategies with established cancer treatments, such as chemotherapy, and immunotherapy. Emphasis is laid on pioneering methods like TAM reprogramming for cancer immunotherapy and the adoption of single-cell technologies for precision intervention. This synthesis seeks to shed light on TAMs’ multifaceted roles in cancer, pinpointing prospective pathways for transformative research and enhancing therapeutic modalities in oncology. Frontiers Media S.A. 2023-11-14 /pmc/articles/PMC10682717/ /pubmed/38035068 http://dx.doi.org/10.3389/fimmu.2023.1295684 Text en Copyright © 2023 Shao, Miao and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shao, Shengwen
Miao, Huilai
Ma, Wenxue
Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title_full Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title_fullStr Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title_full_unstemmed Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title_short Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
title_sort unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682717/
https://www.ncbi.nlm.nih.gov/pubmed/38035068
http://dx.doi.org/10.3389/fimmu.2023.1295684
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