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Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations

BACKGROUND: Histological grade has been regarded as the most important prognostic factor in conventional central chondrosarcoma. To evaluate whether the presence of an extraosseous tumour component is associated with a decreased metastasis-free survival or disease-specific survival and alternatively...

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Autores principales: Laitinen, Minna K., Thorkildsen, Joachim, Morris, Guy, Kurisunkal, Vineet, Stevenson, Jonathan D., Parry, Michael C., Jeys, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682821/
https://www.ncbi.nlm.nih.gov/pubmed/38033413
http://dx.doi.org/10.1016/j.jbo.2023.100514
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author Laitinen, Minna K.
Thorkildsen, Joachim
Morris, Guy
Kurisunkal, Vineet
Stevenson, Jonathan D.
Parry, Michael C.
Jeys, Lee M.
author_facet Laitinen, Minna K.
Thorkildsen, Joachim
Morris, Guy
Kurisunkal, Vineet
Stevenson, Jonathan D.
Parry, Michael C.
Jeys, Lee M.
author_sort Laitinen, Minna K.
collection PubMed
description BACKGROUND: Histological grade has been regarded as the most important prognostic factor in conventional central chondrosarcoma. To evaluate whether the presence of an extraosseous tumour component is associated with a decreased metastasis-free survival or disease-specific survival and alternatively to develop a simple prognostic and clinical decision-making tool. MATERIAL AND METHODS: We searched two prospectively maintained international sarcoma centre databases for primary non metastatic central conventional chondrosarcomas of all grades in pelvis, scapula or long bone location, undergoing curative treatment, diagnosed between 2000 and 2020. Pre-treatment MRI scans were reviewed for the presence of an extraosseous mass. The metastasis-free survival (MFS) and disease-specific survival (DSS) were estimated by the Kaplan-Meier method from surgery to event, death or last follow-up. RESULTS: 336 patients were identified between 2000 and 2020, undergoing surgical treatment for conventional central chondrosarcoma. 111 patients (33 %) had grade 1 tumours, 149 patients (44 %) had grade 2, and 76 patient (23 %) had grade 3 chondrosarcomas determined as the highest grade in the final resected specimen. An extraosseous soft tissue component was more frequent in higher grade tumours (p < 0.001) and present in 200 cases (60 %). None of the patients with an intraosseous tumour developed metastases or died of the disease. For patients with extraosseous tumour component, MFS was 92 % (95 % CI, 96–100) at 2-years and 74 % (95 % CI, 67–81) at 10-years and DSS was 91 % (95 % CI, 87–95) at 2-years and 75 % (95 % CI, 68–82) at 10-years. The MFS and DSS was significantly different (p < 0.001) for those patients with or without an extraosseous tumour component, irrespective of grade or anatomical location. DISCUSSION: The results of this study has shown that the metastatic potential of intraosseous conventional central chondrosarcoma is negligible. The presence of an extraosseous soft tissue component may be used for prognostication and to guide treatment pathways for patients with central cartilage tumours.
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spelling pubmed-106828212023-11-30 Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations Laitinen, Minna K. Thorkildsen, Joachim Morris, Guy Kurisunkal, Vineet Stevenson, Jonathan D. Parry, Michael C. Jeys, Lee M. J Bone Oncol Research Article BACKGROUND: Histological grade has been regarded as the most important prognostic factor in conventional central chondrosarcoma. To evaluate whether the presence of an extraosseous tumour component is associated with a decreased metastasis-free survival or disease-specific survival and alternatively to develop a simple prognostic and clinical decision-making tool. MATERIAL AND METHODS: We searched two prospectively maintained international sarcoma centre databases for primary non metastatic central conventional chondrosarcomas of all grades in pelvis, scapula or long bone location, undergoing curative treatment, diagnosed between 2000 and 2020. Pre-treatment MRI scans were reviewed for the presence of an extraosseous mass. The metastasis-free survival (MFS) and disease-specific survival (DSS) were estimated by the Kaplan-Meier method from surgery to event, death or last follow-up. RESULTS: 336 patients were identified between 2000 and 2020, undergoing surgical treatment for conventional central chondrosarcoma. 111 patients (33 %) had grade 1 tumours, 149 patients (44 %) had grade 2, and 76 patient (23 %) had grade 3 chondrosarcomas determined as the highest grade in the final resected specimen. An extraosseous soft tissue component was more frequent in higher grade tumours (p < 0.001) and present in 200 cases (60 %). None of the patients with an intraosseous tumour developed metastases or died of the disease. For patients with extraosseous tumour component, MFS was 92 % (95 % CI, 96–100) at 2-years and 74 % (95 % CI, 67–81) at 10-years and DSS was 91 % (95 % CI, 87–95) at 2-years and 75 % (95 % CI, 68–82) at 10-years. The MFS and DSS was significantly different (p < 0.001) for those patients with or without an extraosseous tumour component, irrespective of grade or anatomical location. DISCUSSION: The results of this study has shown that the metastatic potential of intraosseous conventional central chondrosarcoma is negligible. The presence of an extraosseous soft tissue component may be used for prognostication and to guide treatment pathways for patients with central cartilage tumours. Elsevier 2023-11-10 /pmc/articles/PMC10682821/ /pubmed/38033413 http://dx.doi.org/10.1016/j.jbo.2023.100514 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Laitinen, Minna K.
Thorkildsen, Joachim
Morris, Guy
Kurisunkal, Vineet
Stevenson, Jonathan D.
Parry, Michael C.
Jeys, Lee M.
Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title_full Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title_fullStr Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title_full_unstemmed Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title_short Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
title_sort intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682821/
https://www.ncbi.nlm.nih.gov/pubmed/38033413
http://dx.doi.org/10.1016/j.jbo.2023.100514
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