Cargando…

Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny

Group B flavin-dependent monooxygenases are employed in swathes of different physiological functions. Despite their collectively large substrate profile, they all harness a flavin-based C4a-(hydro)peroxy intermediate for function. Within this class are the flavin-containing monooxygenases (FMOs), re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nicoll, C.R., Mascotti, M.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682829/ https://www.ncbi.nlm.nih.gov/pubmed/38034983 http://dx.doi.org/10.1016/j.bbadva.2023.100108

Ejemplares similares

Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties
por: Bailleul, Gautier, et al.
Publicado: (2020)

Revisiting the optical properties of the FMO protein
por: Milder, Maaike T. W., et al.
Publicado: (2010)

Discovery of the Odderon by TOTEM experiments and the FMO approach
por: Martynov, Evgenij, et al.
Publicado: (2019)

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
por: El-Serafi, Ibrahim, et al.
Publicado: (2017)

Fluorescence-excitation and Emission Spectroscopy on Single FMO Complexes
por: Löhner, Alexander, et al.
Publicado: (2016)

Evolutionary and structural analyses of the NADPH oxidase family in eukaryotes reveal an initial calcium dependency
por: Massari, Marta, et al.
Publicado: (2022)

Correction: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Publicado: (2017)

Production of drug metabolites by human FMO3 in Escherichia coli
por: Catucci, Gianluca, et al.
Publicado: (2020)

FMO4 shapes immuno‐metabolic reconfiguration in hepatocellular carcinoma
por: Luo, Yan, et al.
Publicado: (2022)

FMO family may serve as novel marker and potential therapeutic target for the peritoneal metastasis in gastric cancer
por: Gong, Xumeng, et al.
Publicado: (2023)

Rapid detection of FMO3 single nucleotide polymorphisms using a pyrosequencing method
por: Park, Jin-Woo, et al.
Publicado: (2022)

Physiology, phylogeny, and LUCA
por: Martin, William F., et al.
Publicado: (2016)

Hybrid QM/MM study of FMO complex with polarized protein-specific charge
por: Jia, Xiangyu, et al.
Publicado: (2015)

Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
por: Gao, Chongliang, et al.
Publicado: (2017)

Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
por: Gao, Chongliang, et al.
Publicado: (2019)

Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study
por: Bryant, Tyler S., et al.
Publicado: (2019)

Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers
por: Tang, Yong-Jun, et al.
Publicado: (2017)

Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer
por: Wu, Lichun, et al.
Publicado: (2023)

Metabolomic and transcriptomic analyses of Fmo5(-/)(- )mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism
por: Phillips, Ian R., et al.
Publicado: (2023)

Non-Markovianity between Site Pairs in FMO Complex Using Discrete-Time Quantum Jump Model
por: Kundu, Mousumi, et al.
Publicado: (2022)

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis
por: Geier, Martina, et al.
Publicado: (2015)

Nicotine Dependence is Associated with Functional Variation in FMO3, an Enzyme that Metabolizes Nicotine in the Brain
por: Teitelbaum, Aaron M., et al.
Publicado: (2017)

Exciton Lifetime Distributions and Population Dynamics in the FMO Protein Complex from Prosthecochloris aestuarii
por: Reinot, Tonu, et al.
Publicado: (2021)

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans
por: Park, Jin-Woo, et al.
Publicado: (2021)

FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity
por: Li, Xingzheng, et al.
Publicado: (2022)

Improving the accuracy of the FMO binding affinity prediction of ligand-receptor complexes containing metals
por: Paciotti, R., et al.
Publicado: (2023)

FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans
por: Choi, Hyo Sub, et al.
Publicado: (2023)

Theoretical Investigation of para Amino-Dichloro Chalcone Isomers. Part II: A DFT Structure–Stability Study of the FMO and NLO Properties
por: Hussein, Haval A., et al.
Publicado: (2023)

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1
por: Mekonnen, Ephrem, et al.
Publicado: (2017)

FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling
por: Czarnocka, Weronika, et al.
Publicado: (2020)

Expression of Concern to: Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
por: Gao, Chongliang, et al.
Publicado: (2020)

Phytoremediation of Cadmium: Physiological, Biochemical, and Molecular Mechanisms
por: Raza, Ali, et al.
Publicado: (2020)

Insect Receptors: Biochemical, Physiological and Molecular Studies
por: Borovsky, Dov
Publicado: (2022)

The Role of Nanoparticles in Response of Plants to Abiotic Stress at Physiological, Biochemical, and Molecular Levels
por: Al-Khayri, Jameel Mohammed, et al.
Publicado: (2023)

Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
por: Dolan, Ciara, et al.
Publicado: (2005)

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients
por: Robinson-Cohen, Cassianne, et al.
Publicado: (2016)

T329S Mutation in the FMO3 Gene Alleviates Lipid Metabolic Diseases in Chickens in the Late Laying Period
por: Song, Jianlou, et al.
Publicado: (2021)

Phylogeny and molecular signatures (conserved proteins and indels) that are specific for the Bacteroidetes and Chlorobi species
por: Gupta, Radhey S, et al.
Publicado: (2007)

Ontogeny and phylogeny: molecular signatures of selection, constraint, and temporal pleiotropy in the development of Drosophila
por: Artieri, Carlo G, et al.
Publicado: (2009)

Physiology, phylogeny, early evolution, and GAPDH
por: Martin, William F., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_911odtekrtvvdnnri3jr84lisk