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Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

The structure-function and optimization studies of Na(V)-inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing Na(V)1.7. With several Na(V) subtypes emerging as potential therapeutic targets, structure-function analysis of Na(V)-inhibiting spider toxins...

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Detalles Bibliográficos
Autores principales:	Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C., Lewis, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682951/ https://www.ncbi.nlm.nih.gov/pubmed/38034993 http://dx.doi.org/10.3389/fphar.2023.1277143

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