Regulation of extracellular progranulin in medial prefrontal cortex

Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major cause of frontotemporal dementia. Most pathogenic GRN mutations cause progranulin haploinsufficiency, so boosting...

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Detalles Bibliográficos
Autores principales: Kaplelach, Azariah K., Fox, Stephanie N., Cook, Anna K., Hall, Justin A., Dannemiller, Ryan S., Jaunarajs, Karen L., Arrant, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682954/
https://www.ncbi.nlm.nih.gov/pubmed/37838007
http://dx.doi.org/10.1016/j.nbd.2023.106326

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