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Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants

The aryl hydrocarbon receptor (AhR) is an inducible transcription factor whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs) containing the core motif 5′-GCGTG-3′. However, AhR bin...

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Detalles Bibliográficos
Autores principales:	Filipovic, David, Qi, Wenjie, Kana, Omar, Marri, Daniel, LeCluyse, Edward L, Andersen, Melvin E, Cuddapah, Suresh, Bhattacharya, Sudin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Computational Toxicology and Databases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682972/ https://www.ncbi.nlm.nih.gov/pubmed/37707797 http://dx.doi.org/10.1093/toxsci/kfad094

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