Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure

[Image: see text] Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like, trans-fused 5,7-bicycli...

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Autores principales: Yan, Chunsheng, Han, Wenyu, Zhou, Qingyang, Niwa, Kanji, Tang, Melody J., Burch, Jessica E., Zhang, Yalong, Delgadillo, David A., Sun, Zuodong, Wu, Zhongshou, Jacobsen, Steven E., Nelson, Hosea, Houk, K. N., Tang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682982/
https://www.ncbi.nlm.nih.gov/pubmed/37948671
http://dx.doi.org/10.1021/jacs.3c10179
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author Yan, Chunsheng
Han, Wenyu
Zhou, Qingyang
Niwa, Kanji
Tang, Melody J.
Burch, Jessica E.
Zhang, Yalong
Delgadillo, David A.
Sun, Zuodong
Wu, Zhongshou
Jacobsen, Steven E.
Nelson, Hosea
Houk, K. N.
Tang, Yi
author_facet Yan, Chunsheng
Han, Wenyu
Zhou, Qingyang
Niwa, Kanji
Tang, Melody J.
Burch, Jessica E.
Zhang, Yalong
Delgadillo, David A.
Sun, Zuodong
Wu, Zhongshou
Jacobsen, Steven E.
Nelson, Hosea
Houk, K. N.
Tang, Yi
author_sort Yan, Chunsheng
collection PubMed
description [Image: see text] Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like, trans-fused 5,7-bicyclic core that is proposed to derive from a (4 + 3) cycloaddition. The core is esterified with d-glucose, which derives from the glycosidic cleavage of a trehalose ester precursor. This glycomodification strategy is different from the commonly observed glycosylation of natural products.
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spelling pubmed-106829822023-11-30 Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure Yan, Chunsheng Han, Wenyu Zhou, Qingyang Niwa, Kanji Tang, Melody J. Burch, Jessica E. Zhang, Yalong Delgadillo, David A. Sun, Zuodong Wu, Zhongshou Jacobsen, Steven E. Nelson, Hosea Houk, K. N. Tang, Yi J Am Chem Soc [Image: see text] Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin, which has a terpene-like, trans-fused 5,7-bicyclic core that is proposed to derive from a (4 + 3) cycloaddition. The core is esterified with d-glucose, which derives from the glycosidic cleavage of a trehalose ester precursor. This glycomodification strategy is different from the commonly observed glycosylation of natural products. American Chemical Society 2023-11-10 /pmc/articles/PMC10682982/ /pubmed/37948671 http://dx.doi.org/10.1021/jacs.3c10179 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Yan, Chunsheng
Han, Wenyu
Zhou, Qingyang
Niwa, Kanji
Tang, Melody J.
Burch, Jessica E.
Zhang, Yalong
Delgadillo, David A.
Sun, Zuodong
Wu, Zhongshou
Jacobsen, Steven E.
Nelson, Hosea
Houk, K. N.
Tang, Yi
Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title_full Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title_fullStr Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title_full_unstemmed Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title_short Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
title_sort genome mining from agriculturally relevant fungi led to a d-glucose esterified polyketide with a terpene-like core structure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682982/
https://www.ncbi.nlm.nih.gov/pubmed/37948671
http://dx.doi.org/10.1021/jacs.3c10179
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