Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs

[Image: see text] OATP1C1 (organic anion-transporting polypeptide 1C1) transports thyroid hormones, particularly thyroxine (T(4)), into human astrocytes. In this study, we investigated the potential of utilizing OATP1C1 to improve the delivery of anti-inflammatory drugs into glial cells. We designed...

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Detalles Bibliográficos
Autores principales: Tonduru, Arun Kumar, Maljaei, Seyed Hamed, Adla, Santosh Kumar, Anamea, Landry, Tampio, Janne, Králová, Adéla, Jalkanen, Aaro J., Espada, Catarina, Santos, Inês Falcato, Montaser, Ahmed B., Rautio, Jarkko, Kronenberger, Thales, Poso, Antti, Huttunen, Kristiina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683023/
https://www.ncbi.nlm.nih.gov/pubmed/37930268
http://dx.doi.org/10.1021/acs.jmedchem.3c01026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683023/
https://www.ncbi.nlm.nih.gov/pubmed/37930268
http://dx.doi.org/10.1021/acs.jmedchem.3c01026

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