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Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355
[Image: see text] Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes named abundisporins B–H (2–8), were isolated from a polypore, Abundisporus violaceus MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated ba...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society and American Society of Pharmacognosy
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683085/ https://www.ncbi.nlm.nih.gov/pubmed/37910033 http://dx.doi.org/10.1021/acs.jnatprod.3c00525 |
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author | Sum, Winnie Chemutai Ebada, Sherif S. Kirchenwitz, Marco Wanga, Lucy Decock, Cony Stradal, Theresia E. B. Matasyoh, Josphat Clement Mándi, Attila Kurtán, Tibor Stadler, Marc |
author_facet | Sum, Winnie Chemutai Ebada, Sherif S. Kirchenwitz, Marco Wanga, Lucy Decock, Cony Stradal, Theresia E. B. Matasyoh, Josphat Clement Mándi, Attila Kurtán, Tibor Stadler, Marc |
author_sort | Sum, Winnie Chemutai |
collection | PubMed |
description | [Image: see text] Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes named abundisporins B–H (2–8), were isolated from a polypore, Abundisporus violaceus MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by HRESIMS data. The absolute configurations of the isolated compounds were determined by using Mosher’s method for 1–4 and TDDFT-ECD calculations for 4 and 5–8. None of the isolated compounds exhibited significant activities in either antimicrobial or cytotoxicity assays. Notably, all of the tested compounds demonstrated neurotrophic effects, with 1 and 6 significantly increasing outgrowth of neurites when treated with 5 ng/mL NGF. |
format | Online Article Text |
id | pubmed-10683085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society and American Society of Pharmacognosy |
record_format | MEDLINE/PubMed |
spelling | pubmed-106830852023-11-30 Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 Sum, Winnie Chemutai Ebada, Sherif S. Kirchenwitz, Marco Wanga, Lucy Decock, Cony Stradal, Theresia E. B. Matasyoh, Josphat Clement Mándi, Attila Kurtán, Tibor Stadler, Marc J Nat Prod [Image: see text] Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes named abundisporins B–H (2–8), were isolated from a polypore, Abundisporus violaceus MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by HRESIMS data. The absolute configurations of the isolated compounds were determined by using Mosher’s method for 1–4 and TDDFT-ECD calculations for 4 and 5–8. None of the isolated compounds exhibited significant activities in either antimicrobial or cytotoxicity assays. Notably, all of the tested compounds demonstrated neurotrophic effects, with 1 and 6 significantly increasing outgrowth of neurites when treated with 5 ng/mL NGF. American Chemical Society and American Society of Pharmacognosy 2023-11-01 /pmc/articles/PMC10683085/ /pubmed/37910033 http://dx.doi.org/10.1021/acs.jnatprod.3c00525 Text en © 2023 The Authors. Published by American Chemical Society and American Society of Pharmacognosy https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Sum, Winnie Chemutai Ebada, Sherif S. Kirchenwitz, Marco Wanga, Lucy Decock, Cony Stradal, Theresia E. B. Matasyoh, Josphat Clement Mándi, Attila Kurtán, Tibor Stadler, Marc Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title | Neurite Outgrowth-Inducing
Drimane-Type Sesquiterpenoids
Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title_full | Neurite Outgrowth-Inducing
Drimane-Type Sesquiterpenoids
Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title_fullStr | Neurite Outgrowth-Inducing
Drimane-Type Sesquiterpenoids
Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title_full_unstemmed | Neurite Outgrowth-Inducing
Drimane-Type Sesquiterpenoids
Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title_short | Neurite Outgrowth-Inducing
Drimane-Type Sesquiterpenoids
Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 |
title_sort | neurite outgrowth-inducing
drimane-type sesquiterpenoids
isolated from cultures of the polypore abundisporus violaceus mucl 56355 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683085/ https://www.ncbi.nlm.nih.gov/pubmed/37910033 http://dx.doi.org/10.1021/acs.jnatprod.3c00525 |
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