Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the f...

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Detalles Bibliográficos
Autores principales: Llinàs-Arias, Pere, Ensenyat-Mendez, Miquel, Íñiguez-Muñoz, Sandra, Orozco, Javier I. J., Valdez, Betsy, Salomon, Matthew P., Matsuba, Chikako, Solivellas-Pieras, Maria, Bedoya-López, Andrés F., Sesé, Borja, Mezger, Anja, Ormestad, Mattias, Unzueta, Fernando, Strand, Siri H., Boiko, Alexander D., Hwang, E Shelley, Cortés, Javier, DiNome, Maggie L., Esteller, Manel, Lupien, Mathieu, Marzese, Diego M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683115/
https://www.ncbi.nlm.nih.gov/pubmed/38017545
http://dx.doi.org/10.1186/s12943-023-01906-8

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