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EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances

The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field each year, the absence of dedicated open-access databases for endophytic microorganism natura...

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Autores principales: Xu, Hong-Quan, Xiao, Huan, Bu, Jin-Hui, Hong, Yan-Feng, Liu, Yu-Hong, Tao, Zi-Yue, Ding, Shu-Fan, Xia, Yi-Tong, Wu, E, Yan, Zhen, Zhang, Wei, Chen, Gong-Xing, Zhu, Feng, Tao, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683116/
https://www.ncbi.nlm.nih.gov/pubmed/38017550
http://dx.doi.org/10.1186/s13321-023-00779-9
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author Xu, Hong-Quan
Xiao, Huan
Bu, Jin-Hui
Hong, Yan-Feng
Liu, Yu-Hong
Tao, Zi-Yue
Ding, Shu-Fan
Xia, Yi-Tong
Wu, E
Yan, Zhen
Zhang, Wei
Chen, Gong-Xing
Zhu, Feng
Tao, Lin
author_facet Xu, Hong-Quan
Xiao, Huan
Bu, Jin-Hui
Hong, Yan-Feng
Liu, Yu-Hong
Tao, Zi-Yue
Ding, Shu-Fan
Xia, Yi-Tong
Wu, E
Yan, Zhen
Zhang, Wei
Chen, Gong-Xing
Zhu, Feng
Tao, Lin
author_sort Xu, Hong-Quan
collection PubMed
description The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field each year, the absence of dedicated open-access databases for endophytic microorganism natural products research is evident. To address the increasing demand for mining and sharing of data resources related to endophytic microorganism natural products, this study introduces EMNPD, a comprehensive endophytic microorganism natural products database comprising manually curated data. Currently, EMNPD offers 6632 natural products from 1017 endophytic microorganisms, targeting 1286 entities (including 94 proteins, 282 cell lines, and 910 species) with 91 diverse bioactivities. It encompasses the physico-chemical properties of natural products, ADMET information, quantitative activity data with their potency, natural products contents with diverse fermentation conditions, systematic taxonomy, and links to various well-established databases. EMNPD aims to function as an open-access knowledge repository for the study of endophytic microorganisms and their natural products, thereby facilitating drug discovery research and exploration of bioactive substances. The database can be accessed at http://emnpd.idrblab.cn/ without the need for registration, enabling researchers to freely download the data. EMNPD is expected to become a valuable resource in the field of endophytic microorganism natural products and contribute to future drug development endeavors.
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spelling pubmed-106831162023-11-30 EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances Xu, Hong-Quan Xiao, Huan Bu, Jin-Hui Hong, Yan-Feng Liu, Yu-Hong Tao, Zi-Yue Ding, Shu-Fan Xia, Yi-Tong Wu, E Yan, Zhen Zhang, Wei Chen, Gong-Xing Zhu, Feng Tao, Lin J Cheminform Database The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field each year, the absence of dedicated open-access databases for endophytic microorganism natural products research is evident. To address the increasing demand for mining and sharing of data resources related to endophytic microorganism natural products, this study introduces EMNPD, a comprehensive endophytic microorganism natural products database comprising manually curated data. Currently, EMNPD offers 6632 natural products from 1017 endophytic microorganisms, targeting 1286 entities (including 94 proteins, 282 cell lines, and 910 species) with 91 diverse bioactivities. It encompasses the physico-chemical properties of natural products, ADMET information, quantitative activity data with their potency, natural products contents with diverse fermentation conditions, systematic taxonomy, and links to various well-established databases. EMNPD aims to function as an open-access knowledge repository for the study of endophytic microorganisms and their natural products, thereby facilitating drug discovery research and exploration of bioactive substances. The database can be accessed at http://emnpd.idrblab.cn/ without the need for registration, enabling researchers to freely download the data. EMNPD is expected to become a valuable resource in the field of endophytic microorganism natural products and contribute to future drug development endeavors. Springer International Publishing 2023-11-28 /pmc/articles/PMC10683116/ /pubmed/38017550 http://dx.doi.org/10.1186/s13321-023-00779-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Database
Xu, Hong-Quan
Xiao, Huan
Bu, Jin-Hui
Hong, Yan-Feng
Liu, Yu-Hong
Tao, Zi-Yue
Ding, Shu-Fan
Xia, Yi-Tong
Wu, E
Yan, Zhen
Zhang, Wei
Chen, Gong-Xing
Zhu, Feng
Tao, Lin
EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title_full EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title_fullStr EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title_full_unstemmed EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title_short EMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
title_sort emnpd: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683116/
https://www.ncbi.nlm.nih.gov/pubmed/38017550
http://dx.doi.org/10.1186/s13321-023-00779-9
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