Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

BACKGROUND: Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of α-syn inclusions in PD pathogenesis remains elusive. This lac...

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Detalles Bibliográficos
Autores principales: Bérard, Morgan, Martínez-Drudis, Laura, Sheta, Razan, El-Agnaf, Omar M. A., Oueslati, Abid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683293/
https://www.ncbi.nlm.nih.gov/pubmed/38012703
http://dx.doi.org/10.1186/s13024-023-00683-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683293/
https://www.ncbi.nlm.nih.gov/pubmed/38012703
http://dx.doi.org/10.1186/s13024-023-00683-8

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