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Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

BACKGROUND: Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of α-syn inclusions in PD pathogenesis remains elusive. This lac...

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Detalles Bibliográficos
Autores principales:	Bérard, Morgan, Martínez-Drudis, Laura, Sheta, Razan, El-Agnaf, Omar M. A., Oueslati, Abid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683293/ https://www.ncbi.nlm.nih.gov/pubmed/38012703 http://dx.doi.org/10.1186/s13024-023-00683-8

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