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Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation

BACKGROUND: Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene transcriptional-variation, we produce a DNA methylation-oriented, driver-gene-wide dataset of regulatory elements in human glioblast...

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Detalles Bibliográficos
Autores principales:	Edrei, Yifat, Levy, Revital, Kaye, Daniel, Marom, Anat, Radlwimmer, Bernhard, Hellman, Asaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683314/ https://www.ncbi.nlm.nih.gov/pubmed/38012713 http://dx.doi.org/10.1186/s13059-023-03094-6

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