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Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo

INTRODUCTION: liver Transplantation is currently the treatment of choice for several terminal liver diseases. Despite the increase in performed transplants, the waiting lists continue to increase. In order to expand the supply of organs, transplantation teams have started to use previously rejected...

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Autores principales: LUGON FERREIRA-JR, ANTONIO CARLOS, MIGUEL, GUSTAVO PEIXOTO SOARES, MOSCON, IARA, ABREU, ISAAC WALKER, AGUIAR, JULIETE BOREL DE OLIVEIRA SILVA, VECCI, THALES RIBEIRO DOS SANTOS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgiões 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683471/
https://www.ncbi.nlm.nih.gov/pubmed/33978120
http://dx.doi.org/10.1590/0100-6991e-20202492
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author LUGON FERREIRA-JR, ANTONIO CARLOS
MIGUEL, GUSTAVO PEIXOTO SOARES
MOSCON, IARA
ABREU, ISAAC WALKER
AGUIAR, JULIETE BOREL DE OLIVEIRA SILVA
VECCI, THALES RIBEIRO DOS SANTOS
author_facet LUGON FERREIRA-JR, ANTONIO CARLOS
MIGUEL, GUSTAVO PEIXOTO SOARES
MOSCON, IARA
ABREU, ISAAC WALKER
AGUIAR, JULIETE BOREL DE OLIVEIRA SILVA
VECCI, THALES RIBEIRO DOS SANTOS
author_sort LUGON FERREIRA-JR, ANTONIO CARLOS
collection PubMed
description INTRODUCTION: liver Transplantation is currently the treatment of choice for several terminal liver diseases. Despite the increase in performed transplants, the waiting lists continue to increase. In order to expand the supply of organs, transplantation teams have started to use previously rejected livers for transplants because of an increased risk of unfavorable outcomes. OBJECTIVE: to evaluate the use of livers of expanded criterion donators. METHODS: retrospective study of medical records. The livers were classified as normal or expanded criteria. The groups were divided in low and high MELD. A multivariate analysis was performed through logistic regression. RESULTS: there was no statistical difference regarding early, late and global mortality between the groups. Decreased survival was observed in patients with high MELD (higher or equal to 20) when they received grafts from expanded criterion donators. The association between the occurrence of cardiorespiratory arrest and presence of elevated total bilirubin in donators was associated with higher mortality rates in expanded criterion livers. CONCLUSION: the overall results are similar, but expanded criteria liver donators was associated with higher mortality in patients with high MELD.
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spelling pubmed-106834712023-11-30 Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo LUGON FERREIRA-JR, ANTONIO CARLOS MIGUEL, GUSTAVO PEIXOTO SOARES MOSCON, IARA ABREU, ISAAC WALKER AGUIAR, JULIETE BOREL DE OLIVEIRA SILVA VECCI, THALES RIBEIRO DOS SANTOS Rev Col Bras Cir Original Article INTRODUCTION: liver Transplantation is currently the treatment of choice for several terminal liver diseases. Despite the increase in performed transplants, the waiting lists continue to increase. In order to expand the supply of organs, transplantation teams have started to use previously rejected livers for transplants because of an increased risk of unfavorable outcomes. OBJECTIVE: to evaluate the use of livers of expanded criterion donators. METHODS: retrospective study of medical records. The livers were classified as normal or expanded criteria. The groups were divided in low and high MELD. A multivariate analysis was performed through logistic regression. RESULTS: there was no statistical difference regarding early, late and global mortality between the groups. Decreased survival was observed in patients with high MELD (higher or equal to 20) when they received grafts from expanded criterion donators. The association between the occurrence of cardiorespiratory arrest and presence of elevated total bilirubin in donators was associated with higher mortality rates in expanded criterion livers. CONCLUSION: the overall results are similar, but expanded criteria liver donators was associated with higher mortality in patients with high MELD. Colégio Brasileiro de Cirurgiões 2021-04-24 /pmc/articles/PMC10683471/ /pubmed/33978120 http://dx.doi.org/10.1590/0100-6991e-20202492 Text en © 2021 Revista do Colégio Brasileiro de Cirurgiões https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
LUGON FERREIRA-JR, ANTONIO CARLOS
MIGUEL, GUSTAVO PEIXOTO SOARES
MOSCON, IARA
ABREU, ISAAC WALKER
AGUIAR, JULIETE BOREL DE OLIVEIRA SILVA
VECCI, THALES RIBEIRO DOS SANTOS
Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title_full Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title_fullStr Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title_full_unstemmed Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title_short Comparison of results on the use of extended criteria liver doners for transplants in Espírito Santo
title_sort comparison of results on the use of extended criteria liver doners for transplants in espírito santo
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683471/
https://www.ncbi.nlm.nih.gov/pubmed/33978120
http://dx.doi.org/10.1590/0100-6991e-20202492
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