Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification

[Image: see text] Peptides are privileged ligands for diverse biomacromolecules, including proteins; however, their utility is often limited due to low membrane permeability and in-cell instability. Here, we report peptide ligand-inserted eDHFR (PLIED) fusion protein as a universal adaptor for targe...

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Detalles Bibliográficos
Autores principales: Fujimura, Akiko, Ishida, Hisashi, Nozaki, Tamiko, Terada, Shuhei, Azumaya, Yuto, Ishiguro, Tadashi, Kamimura, Yugo R., Kujirai, Tomoya, Kurumizaka, Hitoshi, Kono, Hidetoshi, Yamatsugu, Kenzo, Kawashima, Shigehiro A., Kanai, Motomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683481/
https://www.ncbi.nlm.nih.gov/pubmed/38033808
http://dx.doi.org/10.1021/acscentsci.3c00930

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