Cargando…

Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

OBJECTIVES: Chronic obstructive pulmonary disease (COPD) patients have a higher risk of developing diabetes, and studies suggest that inhaled corticosteroids (ICSs) use may be associated with a higher risk of diabetes, particularly at higher doses. This study aims to investigate the effects of ICS u...

Descripción completa

Detalles Bibliográficos
Autores principales: Kholis, Fathur Nur, Pratama, Kevin Gracia, Hadiyanto, Jessica Novia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683519/
https://www.ncbi.nlm.nih.gov/pubmed/38035057
http://dx.doi.org/10.4103/tcmj.tcmj_131_23
_version_ 1785151214133968896
author Kholis, Fathur Nur
Pratama, Kevin Gracia
Hadiyanto, Jessica Novia
author_facet Kholis, Fathur Nur
Pratama, Kevin Gracia
Hadiyanto, Jessica Novia
author_sort Kholis, Fathur Nur
collection PubMed
description OBJECTIVES: Chronic obstructive pulmonary disease (COPD) patients have a higher risk of developing diabetes, and studies suggest that inhaled corticosteroids (ICSs) use may be associated with a higher risk of diabetes, particularly at higher doses. This study aims to investigate the effects of ICS use on the risk of diabetes and blood glucose levels in COPD patients. MATERIALS AND METHODS: A systematic search was carried out on the PubMed, EBSCOhost, and ProQuest databases using the terms “Inhaled Corticosteroids,” “Diabetes,” and “Chronic Obstructive Pulmonary Disease” for the period between 2013 and 2023. The systematic review adhered to the PRISMA 2020 guideline. A meta-analysis was conducted using a random-effects model using the RevMan 5 software. RESULTS: A total of 14 studies were included in the final analysis, with 10 randomized controlled trials (RCTs) and 4 observational studies. Two observational studies investigated the relationship between ICS dose and diabetes risk. A meta-analysis of the RCTs studies showed a nonstatistically significant tendency toward increased blood glucose (odds ratio [OR] 1.07 and 95% confidence interval [CI] 0.88–1.30) after a 52-week follow-up. Whereas the observational studies showed a tendency toward an increased risk of diabetes (OR 1.40 and 95% CI 0.96–2.03). Furthermore, a subgroup meta-analysis of high-dose ICS (>900 μg/day) showed a significant increase in the risk of diabetes (OR 1.20 and 95% CI 1.09–1.32). CONCLUSION: Short-term use of ICS does not have a significant effect on blood glucose. However, long-term use, especially at higher doses, can increase the risk of developing diabetes.
format Online
Article
Text
id pubmed-10683519
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-106835192023-11-30 Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis Kholis, Fathur Nur Pratama, Kevin Gracia Hadiyanto, Jessica Novia Tzu Chi Med J Original Article OBJECTIVES: Chronic obstructive pulmonary disease (COPD) patients have a higher risk of developing diabetes, and studies suggest that inhaled corticosteroids (ICSs) use may be associated with a higher risk of diabetes, particularly at higher doses. This study aims to investigate the effects of ICS use on the risk of diabetes and blood glucose levels in COPD patients. MATERIALS AND METHODS: A systematic search was carried out on the PubMed, EBSCOhost, and ProQuest databases using the terms “Inhaled Corticosteroids,” “Diabetes,” and “Chronic Obstructive Pulmonary Disease” for the period between 2013 and 2023. The systematic review adhered to the PRISMA 2020 guideline. A meta-analysis was conducted using a random-effects model using the RevMan 5 software. RESULTS: A total of 14 studies were included in the final analysis, with 10 randomized controlled trials (RCTs) and 4 observational studies. Two observational studies investigated the relationship between ICS dose and diabetes risk. A meta-analysis of the RCTs studies showed a nonstatistically significant tendency toward increased blood glucose (odds ratio [OR] 1.07 and 95% confidence interval [CI] 0.88–1.30) after a 52-week follow-up. Whereas the observational studies showed a tendency toward an increased risk of diabetes (OR 1.40 and 95% CI 0.96–2.03). Furthermore, a subgroup meta-analysis of high-dose ICS (>900 μg/day) showed a significant increase in the risk of diabetes (OR 1.20 and 95% CI 1.09–1.32). CONCLUSION: Short-term use of ICS does not have a significant effect on blood glucose. However, long-term use, especially at higher doses, can increase the risk of developing diabetes. Wolters Kluwer - Medknow 2023-10-06 /pmc/articles/PMC10683519/ /pubmed/38035057 http://dx.doi.org/10.4103/tcmj.tcmj_131_23 Text en Copyright: © 2023 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kholis, Fathur Nur
Pratama, Kevin Gracia
Hadiyanto, Jessica Novia
Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_full Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_fullStr Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_full_unstemmed Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_short Association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
title_sort association between inhaled corticosteroid use and risk of hyperglycemia in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683519/
https://www.ncbi.nlm.nih.gov/pubmed/38035057
http://dx.doi.org/10.4103/tcmj.tcmj_131_23
work_keys_str_mv AT kholisfathurnur associationbetweeninhaledcorticosteroiduseandriskofhyperglycemiainpatientswithchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis
AT pratamakevingracia associationbetweeninhaledcorticosteroiduseandriskofhyperglycemiainpatientswithchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis
AT hadiyantojessicanovia associationbetweeninhaledcorticosteroiduseandriskofhyperglycemiainpatientswithchronicobstructivepulmonarydiseaseasystematicreviewandmetaanalysis