Cargando…

Antibiotics that target mitochondria extend lifespan in C. elegans

Aging is a continuous degenerative process caused by a progressive decline of cell and tissue functions in an organism. It is induced by the accumulation of damage that affects normal cellular processes, ultimately leading to cell death. It has been speculated for many years that mitochondria play a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bonuccelli, Gloria, Brooks, Darren R., Shepherd, Sally, Sotgia, Federica, Lisanti, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683609/ https://www.ncbi.nlm.nih.gov/pubmed/37950722 http://dx.doi.org/10.18632/aging.205229

Ejemplares similares

Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation
por: Bonuccelli, Gloria, et al.
Publicado: (2022)

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways
por: Bonuccelli, Gloria, et al.
Publicado: (2018)

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
por: De Francesco, Ernestina Marianna, et al.
Publicado: (2017)

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling
por: Peiris-Pagès, Maria, et al.
Publicado: (2018)

Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
por: Fiorillo, Marco, et al.
Publicado: (2019)

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds
por: Ózsvári, Béla, et al.
Publicado: (2020)

Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy
por: Ozsvari, Bela, et al.
Publicado: (2017)

Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity
por: Bonuccelli, Gloria, et al.
Publicado: (2016)

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease
por: Lamb, Rebecca, et al.
Publicado: (2015)

D-beta-hydroxybutyrate extends lifespan in C. elegans
por: Edwards, Clare, et al.
Publicado: (2014)

Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast
por: Ozsvari, Bela, et al.
Publicado: (2017)

Targeting mitochondria to extend physically active lifespan
por: Ahn, Bumsoo
Publicado: (2023)

A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX
por: Sotgia, Federica, et al.
Publicado: (2018)

An Engineering Approach to Extending Lifespan in C. elegans
por: Sagi, Dror, et al.
Publicado: (2012)

Dodecyl-TPP Targets Mitochondria and Potently Eradicates Cancer Stem Cells (CSCs): Synergy With FDA-Approved Drugs and Natural Compounds (Vitamin C and Berberine)
por: De Francesco, Ernestina Marianna, et al.
Publicado: (2019)

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
por: Lamb, Rebecca, et al.
Publicado: (2014)

Bacillus subtilis TO-A extends the lifespan of Caenorhabditis elegans
por: SAITO, Ryuichi, et al.
Publicado: (2023)

Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans
por: Liu, Dongliang, et al.
Publicado: (2020)

Mitochondrial translational defect extends lifespan in C. elegans by activating UPR(mt)
por: Guo, Miaomiao, et al.
Publicado: (2023)

C22 disrupts embryogenesis and extends C. elegans lifespan
por: Beydoun, Safa, et al.
Publicado: (2023)

Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction
por: Shintani, Tomoya, et al.
Publicado: (2018)

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)
por: Ozsvari, Bela, et al.
Publicado: (2018)

Pharmacological classes that extend lifespan of Caenorhabditis elegans
por: Carretero, Maria, et al.
Publicado: (2015)

A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis
por: Ozsvari, Bela, et al.
Publicado: (2017)

Metformin extends C. elegans lifespan through lysosomal pathway
por: Chen, Jie, et al.
Publicado: (2017)

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner
por: Brandstädt, Sven, et al.
Publicado: (2013)

Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
por: Matei, Ioan Valentin, et al.
Publicado: (2021)

Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features
por: Ribeiro, Caio, et al.
Publicado: (2023)

MitoTracker Deep Red (MTDR) Is a Metabolic Inhibitor for Targeting Mitochondria and Eradicating Cancer Stem Cells (CSCs), With Anti-Tumor and Anti-Metastatic Activity In Vivo
por: Sargiacomo, Camillo, et al.
Publicado: (2021)

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans
por: Edwards, Clare B., et al.
Publicado: (2013)

Curcumin Acetylsalicylate Extends the Lifespan of Caenorhabditis elegans
por: Zhou, Lei, et al.
Publicado: (2021)

l-Theanine extends lifespan of adult Caenorhabditis elegans
por: Zarse, Kim, et al.
Publicado: (2012)

Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer: Companion diagnostics for cancer therapy
por: Sotgia, Federica, et al.
Publicado: (2017)

Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers: Companion diagnostics for personalized medicine
por: Sotgia, Federica, et al.
Publicado: (2017)

Mitochondrial markers predict survival and progression in non-small cell lung cancer (NSCLC) patients: Use as companion diagnostics
por: Sotgia, Federica, et al.
Publicado: (2017)

The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan
por: Collins, James J., et al.
Publicado: (2008)

The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms
por: García-Casas, Paloma, et al.
Publicado: (2019)

Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
por: Xu, Chen, et al.
Publicado: (2018)

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals
por: Wan, Qin-Li, et al.
Publicado: (2019)

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality
por: Rangaraju, Sunitha, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hh9ahb06sh9dr21uamobrm4uk5