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Ocular metastasis from renal malignancies – A comprehensive review

The most common cause of intraocular mass is metastasis from other tumors. Renal malignancies, though rare, have a substantial number of cases with ocular metastasis, few of which were misdiagnosed. Many a times renal malignancies present with ocular manifestations before the primary diagnosis. Here...

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Autores principales: Jindal, Akriti, Kapatia, Gargi, Gupta, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683680/
https://www.ncbi.nlm.nih.gov/pubmed/37787223
http://dx.doi.org/10.4103/IJO.IJO_3073_22
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author Jindal, Akriti
Kapatia, Gargi
Gupta, Gaurav
author_facet Jindal, Akriti
Kapatia, Gargi
Gupta, Gaurav
author_sort Jindal, Akriti
collection PubMed
description The most common cause of intraocular mass is metastasis from other tumors. Renal malignancies, though rare, have a substantial number of cases with ocular metastasis, few of which were misdiagnosed. Many a times renal malignancies present with ocular manifestations before the primary diagnosis. Here in this article, we comprehensively reviewed 106 cases of ocular metastasis from renal malignancies published till date to the best of our knowledge. The eye is a rare site for distant metastasis because of the lack of a lymphatic system. The most common ocular structures to get involved in distant metastasis are the uveal tract, i.e., choroid, iris, and ciliary body. The most common renal tumor which metastasizes to eyes is renal cell carcinoma (RCC). RCC accounts for less than 2% of all ophthalmic metastases. Out of total 106 cases, the type of renal malignancy was known in 95 cases only, of which 92 had RCC, 1 Wilm’s tumor, 1 rhabdoid tumor, and 1 medullary carcinoma. The age ranged widely from 2 weeks old to 81 years old. The male to female ratio was 3.4:1. In total, 67.4% of cases had a previous history of RCC, while the rest 32.6% primarily presented with ophthalmic manifestations first. Treatment modalities included enucleation of the eye, debulking surgery followed by radiotherapy and/or chemotherapy and/or immunotherapy.
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spelling pubmed-106836802023-11-30 Ocular metastasis from renal malignancies – A comprehensive review Jindal, Akriti Kapatia, Gargi Gupta, Gaurav Indian J Ophthalmol Review Article The most common cause of intraocular mass is metastasis from other tumors. Renal malignancies, though rare, have a substantial number of cases with ocular metastasis, few of which were misdiagnosed. Many a times renal malignancies present with ocular manifestations before the primary diagnosis. Here in this article, we comprehensively reviewed 106 cases of ocular metastasis from renal malignancies published till date to the best of our knowledge. The eye is a rare site for distant metastasis because of the lack of a lymphatic system. The most common ocular structures to get involved in distant metastasis are the uveal tract, i.e., choroid, iris, and ciliary body. The most common renal tumor which metastasizes to eyes is renal cell carcinoma (RCC). RCC accounts for less than 2% of all ophthalmic metastases. Out of total 106 cases, the type of renal malignancy was known in 95 cases only, of which 92 had RCC, 1 Wilm’s tumor, 1 rhabdoid tumor, and 1 medullary carcinoma. The age ranged widely from 2 weeks old to 81 years old. The male to female ratio was 3.4:1. In total, 67.4% of cases had a previous history of RCC, while the rest 32.6% primarily presented with ophthalmic manifestations first. Treatment modalities included enucleation of the eye, debulking surgery followed by radiotherapy and/or chemotherapy and/or immunotherapy. Wolters Kluwer - Medknow 2023-10 2023-09-29 /pmc/articles/PMC10683680/ /pubmed/37787223 http://dx.doi.org/10.4103/IJO.IJO_3073_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Jindal, Akriti
Kapatia, Gargi
Gupta, Gaurav
Ocular metastasis from renal malignancies – A comprehensive review
title Ocular metastasis from renal malignancies – A comprehensive review
title_full Ocular metastasis from renal malignancies – A comprehensive review
title_fullStr Ocular metastasis from renal malignancies – A comprehensive review
title_full_unstemmed Ocular metastasis from renal malignancies – A comprehensive review
title_short Ocular metastasis from renal malignancies – A comprehensive review
title_sort ocular metastasis from renal malignancies – a comprehensive review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683680/
https://www.ncbi.nlm.nih.gov/pubmed/37787223
http://dx.doi.org/10.4103/IJO.IJO_3073_22
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