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Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors

Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate r...

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Autores principales: Vukolova, Marina N., Yen, Laura Y., Khmyz, Margarita I., Sobolevsky, Alexander I., Yelshanskaya, Maria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683763/
https://www.ncbi.nlm.nih.gov/pubmed/38033869
http://dx.doi.org/10.3389/fcell.2023.1252953
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author Vukolova, Marina N.
Yen, Laura Y.
Khmyz, Margarita I.
Sobolevsky, Alexander I.
Yelshanskaya, Maria V.
author_facet Vukolova, Marina N.
Yen, Laura Y.
Khmyz, Margarita I.
Sobolevsky, Alexander I.
Yelshanskaya, Maria V.
author_sort Vukolova, Marina N.
collection PubMed
description Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors, in the pathogenesis and treatment of Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis. Although both AMPA and kainate receptors represent promising therapeutic targets for the treatment of these diseases, many of their antagonists show adverse side effects. Further studies of factors affecting the selective subunit expression and trafficking of AMPA and kainate receptors, and a reasonable approach to their regulation by the recently identified novel compounds remain promising directions for pharmacological research.
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spelling pubmed-106837632023-11-30 Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors Vukolova, Marina N. Yen, Laura Y. Khmyz, Margarita I. Sobolevsky, Alexander I. Yelshanskaya, Maria V. Front Cell Dev Biol Cell and Developmental Biology Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors, in the pathogenesis and treatment of Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis. Although both AMPA and kainate receptors represent promising therapeutic targets for the treatment of these diseases, many of their antagonists show adverse side effects. Further studies of factors affecting the selective subunit expression and trafficking of AMPA and kainate receptors, and a reasonable approach to their regulation by the recently identified novel compounds remain promising directions for pharmacological research. Frontiers Media S.A. 2023-10-24 /pmc/articles/PMC10683763/ /pubmed/38033869 http://dx.doi.org/10.3389/fcell.2023.1252953 Text en Copyright © 2023 Vukolova, Yen, Khmyz, Sobolevsky and Yelshanskaya. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Vukolova, Marina N.
Yen, Laura Y.
Khmyz, Margarita I.
Sobolevsky, Alexander I.
Yelshanskaya, Maria V.
Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title_full Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title_fullStr Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title_full_unstemmed Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title_short Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
title_sort parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of ampa and kainate subtypes of ionotropic glutamate receptors
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683763/
https://www.ncbi.nlm.nih.gov/pubmed/38033869
http://dx.doi.org/10.3389/fcell.2023.1252953
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