Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism

Lysine succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the tricarboxylic acid cycle. Deficiency of succinyl-CoA synthetase (SCS), the tricarboxylic acid cycle enzyme catalyzing the interconversion of succinyl-CoA to succinate, results in mitoch...

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Detalles Bibliográficos
Autores principales: Lancaster, Makayla S., Kim, Byungwook, Doud, Emma H., Tate, Mason D., Sharify, Ahmad D., Gao, Hongyu, Chen, Duojiao, Simpson, Ed, Gillespie, Patrick, Chu, Xiaona, Miller, Marcus J., Wang, Yue, Liu, Yunlong, Mosley, Amber L., Kim, Jungsu, Graham, Brett H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683835/
https://www.ncbi.nlm.nih.gov/pubmed/37819759
http://dx.doi.org/10.1016/j.celrep.2023.113241

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