Volitional activation of remote place representations with a hippocampal brain-machine interface

The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations of people, events, and places, including the hippocampus’ map-like representations of familiar environments. However, whether representations in such “cognitive maps” can be volitionally accessed is unknown. We developed a brain-machine interface to test if rats can do so by controlling their hippocampal activity in a flexible, goal-directed, and model-based manner. We found that rats can efficiently navigate or direct objects to arbitrary goal locations within a virtual reality arena solely by activating and sustaining appropriate hippocampal representations of remote places. This provides insight into the mechanisms underlying episodic memory recall, mental simulation/planning, and imagination, and opens up possibilities for high-level neural prosthetics utilizing hippocampal representations.