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Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide that is etiologically linked to a previous hepatitis B infection. We describe two cases of HCC metastasis to the oral cavity in 60- and 67-year-old male patients. The first case was a diffuse, hard swelling in the left b...

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Autores principales: Reesha, K, Mohamed, Shameena Pazhaningal, Varma, Sujatha, Nair, Resmi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683923/
https://www.ncbi.nlm.nih.gov/pubmed/38033937
http://dx.doi.org/10.4103/jomfp.jomfp_515_22
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author Reesha, K
Mohamed, Shameena Pazhaningal
Varma, Sujatha
Nair, Resmi G.
author_facet Reesha, K
Mohamed, Shameena Pazhaningal
Varma, Sujatha
Nair, Resmi G.
author_sort Reesha, K
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide that is etiologically linked to a previous hepatitis B infection. We describe two cases of HCC metastasis to the oral cavity in 60- and 67-year-old male patients. The first case was a diffuse, hard swelling in the left body of the mandible. Histopathologic and immunohistochemical analysis was done, and a positive for CK7, CK19, HEPPAR and TTF and a negative for NAPSIN were found to be diagnostic of metastatic HCC. Subsequent examination of the serum alfa- fetoprotein (AFP) level showed a high value of 450 ng/ml, confirmatory of HCC. The second case was a pedunculated, reddish, mobile soft tissue growth on the retromolar region. Its macroscopic and histopathologic features themselves were confirmatory of HCC, and the elicited history was corroborant of metastasis.
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spelling pubmed-106839232023-11-30 Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases Reesha, K Mohamed, Shameena Pazhaningal Varma, Sujatha Nair, Resmi G. J Oral Maxillofac Pathol Case Report Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide that is etiologically linked to a previous hepatitis B infection. We describe two cases of HCC metastasis to the oral cavity in 60- and 67-year-old male patients. The first case was a diffuse, hard swelling in the left body of the mandible. Histopathologic and immunohistochemical analysis was done, and a positive for CK7, CK19, HEPPAR and TTF and a negative for NAPSIN were found to be diagnostic of metastatic HCC. Subsequent examination of the serum alfa- fetoprotein (AFP) level showed a high value of 450 ng/ml, confirmatory of HCC. The second case was a pedunculated, reddish, mobile soft tissue growth on the retromolar region. Its macroscopic and histopathologic features themselves were confirmatory of HCC, and the elicited history was corroborant of metastasis. Wolters Kluwer - Medknow 2023 2023-09-12 /pmc/articles/PMC10683923/ /pubmed/38033937 http://dx.doi.org/10.4103/jomfp.jomfp_515_22 Text en Copyright: © 2023 Journal of Oral and Maxillofacial Pathology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Reesha, K
Mohamed, Shameena Pazhaningal
Varma, Sujatha
Nair, Resmi G.
Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title_full Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title_fullStr Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title_full_unstemmed Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title_short Metastatic hepatocellular carcinoma of the oral cavity - A report of two cases
title_sort metastatic hepatocellular carcinoma of the oral cavity - a report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683923/
https://www.ncbi.nlm.nih.gov/pubmed/38033937
http://dx.doi.org/10.4103/jomfp.jomfp_515_22
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