Role of immunometabolism during congenital cytomegalovirus infection

Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter...

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Autores principales: Zwezdaryk, Kevin J., Kaur, Amitinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683969/
https://www.ncbi.nlm.nih.gov/pubmed/38037590
http://dx.doi.org/10.1097/IN9.0000000000000034
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author Zwezdaryk, Kevin J.
Kaur, Amitinder
author_facet Zwezdaryk, Kevin J.
Kaur, Amitinder
author_sort Zwezdaryk, Kevin J.
collection PubMed
description Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter metabolism in uninfected neighboring cells. In this mini review, we discuss how CMV infection may impact immune function through metabolic pathways. We discuss how immune cells differ between maternal and decidual compartments and how altered immunometabolism may contribute to congenital infections.
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spelling pubmed-106839692023-11-30 Role of immunometabolism during congenital cytomegalovirus infection Zwezdaryk, Kevin J. Kaur, Amitinder Immunometabolism (Cobham) Viewpoint Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter metabolism in uninfected neighboring cells. In this mini review, we discuss how CMV infection may impact immune function through metabolic pathways. We discuss how immune cells differ between maternal and decidual compartments and how altered immunometabolism may contribute to congenital infections. Lippincott Williams & Wilkins 2023-11-28 /pmc/articles/PMC10683969/ /pubmed/38037590 http://dx.doi.org/10.1097/IN9.0000000000000034 Text en Copyright © 2023 The Author(s), Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This paper is published under Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Viewpoint
Zwezdaryk, Kevin J.
Kaur, Amitinder
Role of immunometabolism during congenital cytomegalovirus infection
title Role of immunometabolism during congenital cytomegalovirus infection
title_full Role of immunometabolism during congenital cytomegalovirus infection
title_fullStr Role of immunometabolism during congenital cytomegalovirus infection
title_full_unstemmed Role of immunometabolism during congenital cytomegalovirus infection
title_short Role of immunometabolism during congenital cytomegalovirus infection
title_sort role of immunometabolism during congenital cytomegalovirus infection
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683969/
https://www.ncbi.nlm.nih.gov/pubmed/38037590
http://dx.doi.org/10.1097/IN9.0000000000000034
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