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Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

The prenylated form of the human 2′-5′-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic. However, the OAS1 ortholog...

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Detalles Bibliográficos
Autores principales:	Lytras, Spyros, Wickenhagen, Arthur, Sugrue, Elena, Stewart, Douglas G., Swingler, Simon, Sims, Anna, Jackson Ireland, Hollie, Davies, Emma L., Ludlam, Eliza M., Li, Zhuonan, Hughes, Joseph, Wilson, Sam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Short Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683996/ https://www.ncbi.nlm.nih.gov/pubmed/38015855 http://dx.doi.org/10.1371/journal.pbio.3002398

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