Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice

Astrocyte-specific ion pump α2-Na(+)/K(+)-ATPase plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we test the effect of Atp1a2 mRNA-specific antisense oligonucleotides (ASOs) to induce α2-Na(+)/K(+)-ATPase knockdown in the widely used ALS animal model, SOD1*G93...

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Detalles Bibliográficos
Autores principales: Iyer, Abhirami K., Schoch, Kathleen M., Verbeck, Anthony, Galasso, Grant, Chen, Hao, Smith, Sarah, Oldenborg, Anna, Miller, Timothy M., Karch, Celeste M., Bonni, Azad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683999/
https://www.ncbi.nlm.nih.gov/pubmed/38015828
http://dx.doi.org/10.1371/journal.pone.0294731

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