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A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer and the increases risk of developing extracolonic cancers. We present the first case of pediatric-onset LS with recurrent adenomatous colonic polyps presenting with rectal prolapse. This case highlights the importance of con...

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Autores principales: Liepert, Maryah, Brundler, Marie-Anne, Galante, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684175/
https://www.ncbi.nlm.nih.gov/pubmed/38034465
http://dx.doi.org/10.1097/PG9.0000000000000354
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author Liepert, Maryah
Brundler, Marie-Anne
Galante, Gary J.
author_facet Liepert, Maryah
Brundler, Marie-Anne
Galante, Gary J.
author_sort Liepert, Maryah
collection PubMed
description Lynch syndrome (LS) is the most common cause of inherited colorectal cancer and the increases risk of developing extracolonic cancers. We present the first case of pediatric-onset LS with recurrent adenomatous colonic polyps presenting with rectal prolapse. This case highlights the importance of considering polyposis syndromes such as LS as possible diagnoses for pediatric patients who present with colorectal adenomatous polyps, as well as the need to consider immunohistochemical staining of polyps for mismatch repair protein expression in pediatric populations to rule out LS as a diagnosis. We demonstrate the need to consider pediatric patients in LS guidelines.
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spelling pubmed-106841752023-11-30 A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps Liepert, Maryah Brundler, Marie-Anne Galante, Gary J. JPGN Rep Case Report Lynch syndrome (LS) is the most common cause of inherited colorectal cancer and the increases risk of developing extracolonic cancers. We present the first case of pediatric-onset LS with recurrent adenomatous colonic polyps presenting with rectal prolapse. This case highlights the importance of considering polyposis syndromes such as LS as possible diagnoses for pediatric patients who present with colorectal adenomatous polyps, as well as the need to consider immunohistochemical staining of polyps for mismatch repair protein expression in pediatric populations to rule out LS as a diagnosis. We demonstrate the need to consider pediatric patients in LS guidelines. Lippincott Williams & Wilkins, Inc. 2023-08-28 /pmc/articles/PMC10684175/ /pubmed/38034465 http://dx.doi.org/10.1097/PG9.0000000000000354 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Liepert, Maryah
Brundler, Marie-Anne
Galante, Gary J.
A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title_full A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title_fullStr A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title_full_unstemmed A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title_short A Rare Presentation of Pediatric Lynch Syndrome Presenting with Recurrent Adenomatous Polyps
title_sort rare presentation of pediatric lynch syndrome presenting with recurrent adenomatous polyps
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684175/
https://www.ncbi.nlm.nih.gov/pubmed/38034465
http://dx.doi.org/10.1097/PG9.0000000000000354
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