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Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study

To investigate risk factors for mortality from sepsis in an intensive care unit (ICU) in Quito-Ecuador and their association to adherence to Surviving Sepsis Campaign recommendations. Prospective cohort study of patients with severe sepsis/septic shock admitted to the ICU of a public Ecuadorian hosp...

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Autores principales: Vélez, Jorge W., Aragon, Davi C., Donadi, Eduardo A., Carlotti, Ana P.C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684228/
https://www.ncbi.nlm.nih.gov/pubmed/35356943
http://dx.doi.org/10.1097/MD.0000000000029096
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author Vélez, Jorge W.
Aragon, Davi C.
Donadi, Eduardo A.
Carlotti, Ana P.C.P.
author_facet Vélez, Jorge W.
Aragon, Davi C.
Donadi, Eduardo A.
Carlotti, Ana P.C.P.
author_sort Vélez, Jorge W.
collection PubMed
description To investigate risk factors for mortality from sepsis in an intensive care unit (ICU) in Quito-Ecuador and their association to adherence to Surviving Sepsis Campaign recommendations. Prospective cohort study of patients with severe sepsis/septic shock admitted to the ICU of a public Ecuadorian hospital from March, 2018 to March, 2019. Demographic, clinical, treatment, and outcome data were collected from patients’ health records. Patients were divided into 2 groups according to ICU survival or death. Log-binomial regression models were used to identify risk factors for mortality. In total, 154 patients were included. Patients who died in the ICU (n = 42; 27.3%) had higher sequential organ failure assessment score (median 11.5 vs 9; P<.01), more organ dysfunction (median 4 vs 3; P<.0001), and received greater volumes of fluid resuscitation in the first 6 hours (median 800 vs 600 mL; P = .01). Dysfunction of > 2 organs was a risk factor for mortality (relative risks [RR] 3.80, 95% CI 1.33-10.86), while successful early resuscitation (RR 0.32, 95% CI 0.15-0.70), successful empirical antibiotic treatment (RR 0.38, 95%CI 0.18-0.82), and antibiotic de-escalation (RR 0.28, 95%CI 0.13-0.61) were protective factors. Dysfunction of >2 organs was a risk factor for mortality from sepsis while successful early resuscitation and appropriate antibiotic treatment were protective.
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spelling pubmed-106842282023-11-30 Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study Vélez, Jorge W. Aragon, Davi C. Donadi, Eduardo A. Carlotti, Ana P.C.P. Medicine (Baltimore) Observational Study To investigate risk factors for mortality from sepsis in an intensive care unit (ICU) in Quito-Ecuador and their association to adherence to Surviving Sepsis Campaign recommendations. Prospective cohort study of patients with severe sepsis/septic shock admitted to the ICU of a public Ecuadorian hospital from March, 2018 to March, 2019. Demographic, clinical, treatment, and outcome data were collected from patients’ health records. Patients were divided into 2 groups according to ICU survival or death. Log-binomial regression models were used to identify risk factors for mortality. In total, 154 patients were included. Patients who died in the ICU (n = 42; 27.3%) had higher sequential organ failure assessment score (median 11.5 vs 9; P<.01), more organ dysfunction (median 4 vs 3; P<.0001), and received greater volumes of fluid resuscitation in the first 6 hours (median 800 vs 600 mL; P = .01). Dysfunction of > 2 organs was a risk factor for mortality (relative risks [RR] 3.80, 95% CI 1.33-10.86), while successful early resuscitation (RR 0.32, 95% CI 0.15-0.70), successful empirical antibiotic treatment (RR 0.38, 95%CI 0.18-0.82), and antibiotic de-escalation (RR 0.28, 95%CI 0.13-0.61) were protective factors. Dysfunction of >2 organs was a risk factor for mortality from sepsis while successful early resuscitation and appropriate antibiotic treatment were protective. Lippincott Williams & Wilkins 2022-03-18 /pmc/articles/PMC10684228/ /pubmed/35356943 http://dx.doi.org/10.1097/MD.0000000000029096 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Observational Study
Vélez, Jorge W.
Aragon, Davi C.
Donadi, Eduardo A.
Carlotti, Ana P.C.P.
Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title_full Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title_fullStr Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title_full_unstemmed Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title_short Risk factors for mortality from sepsis in an intensive care unit in Ecuador: A prospective study
title_sort risk factors for mortality from sepsis in an intensive care unit in ecuador: a prospective study
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684228/
https://www.ncbi.nlm.nih.gov/pubmed/35356943
http://dx.doi.org/10.1097/MD.0000000000029096
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