Cargando…

The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis

BACKGROUND: Rheumatoid arthritis (RA) is one of the common inflammatory diseases with arthritis due to a malfunction of the immune system. The treatments for RA include surgery, physiotherapy, occupational therapies, and medication. The representative treatment is medication and its usage has improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Moon, Jeong-Hyun, Sung, Won-Suk, Choi, Seong-Kyeong, Kim, Jung-Hyun, Suh, Jin-woo, Kim, Joo-Hee, Seo, Byung-Kwan, Lee, Seung-Deok, Kim, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684229/
https://www.ncbi.nlm.nih.gov/pubmed/35356947
http://dx.doi.org/10.1097/MD.0000000000029105
_version_ 1785151357739597824
author Moon, Jeong-Hyun
Sung, Won-Suk
Choi, Seong-Kyeong
Kim, Jung-Hyun
Suh, Jin-woo
Kim, Joo-Hee
Seo, Byung-Kwan
Lee, Seung-Deok
Kim, Eun-Jung
author_facet Moon, Jeong-Hyun
Sung, Won-Suk
Choi, Seong-Kyeong
Kim, Jung-Hyun
Suh, Jin-woo
Kim, Joo-Hee
Seo, Byung-Kwan
Lee, Seung-Deok
Kim, Eun-Jung
author_sort Moon, Jeong-Hyun
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA) is one of the common inflammatory diseases with arthritis due to a malfunction of the immune system. The treatments for RA include surgery, physiotherapy, occupational therapies, and medication. The representative treatment is medication and its usage has improved through several guidelines. However, it has some limitations and occurs adverse effects. Meanwhile, traditional Chinese medicine treatments have been used for RA treatment and Wu tou decoction (WTD) is one of them. Regardless of recent studies about WTD’s efficacy on RA, there has been no systematic review on this issue. Therefore, this review will focus on the effectiveness and safety of WTD on RA. METHODS: The search for randomized controlled trial about WTD on RA will be performed using multiple electronic databases, manual searches, and the author’s e-mail if necessary. According to predefined criteria, randomized controlled trials will be selected and summarization will be performed by the data on study participants, result measurements, interventions, adverse events, and risk of bias. Disease activity score including effective rate, swollen joint count, tender joint count, morning stiffness will be primary outcome measures while blood test about RA including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factors, and adverse events will be secondary outcome measures. We will perform meta-analysis by using Review Manager software, assess the risk of bias by Cochrane Collaboration “risk of bias” tool, and determine the quality of evidence by Grades of Recommendation, Assessment, Development, and Evaluation. RESULTS: This study we will investigate the clinical evidence of the effectiveness and safety of WTD on RA. CONCLUSION: For the RA patients and clinicians, our study will be informative. It can be also a great help for the researchers and policy makers who concentrates on conservative management for RA. TRIAL REGISTRATION NUMBER: INPLASY; INPLASY202220099
format Online
Article
Text
id pubmed-10684229
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-106842292023-11-30 The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis Moon, Jeong-Hyun Sung, Won-Suk Choi, Seong-Kyeong Kim, Jung-Hyun Suh, Jin-woo Kim, Joo-Hee Seo, Byung-Kwan Lee, Seung-Deok Kim, Eun-Jung Medicine (Baltimore) Study Protocol Systematic Review BACKGROUND: Rheumatoid arthritis (RA) is one of the common inflammatory diseases with arthritis due to a malfunction of the immune system. The treatments for RA include surgery, physiotherapy, occupational therapies, and medication. The representative treatment is medication and its usage has improved through several guidelines. However, it has some limitations and occurs adverse effects. Meanwhile, traditional Chinese medicine treatments have been used for RA treatment and Wu tou decoction (WTD) is one of them. Regardless of recent studies about WTD’s efficacy on RA, there has been no systematic review on this issue. Therefore, this review will focus on the effectiveness and safety of WTD on RA. METHODS: The search for randomized controlled trial about WTD on RA will be performed using multiple electronic databases, manual searches, and the author’s e-mail if necessary. According to predefined criteria, randomized controlled trials will be selected and summarization will be performed by the data on study participants, result measurements, interventions, adverse events, and risk of bias. Disease activity score including effective rate, swollen joint count, tender joint count, morning stiffness will be primary outcome measures while blood test about RA including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factors, and adverse events will be secondary outcome measures. We will perform meta-analysis by using Review Manager software, assess the risk of bias by Cochrane Collaboration “risk of bias” tool, and determine the quality of evidence by Grades of Recommendation, Assessment, Development, and Evaluation. RESULTS: This study we will investigate the clinical evidence of the effectiveness and safety of WTD on RA. CONCLUSION: For the RA patients and clinicians, our study will be informative. It can be also a great help for the researchers and policy makers who concentrates on conservative management for RA. TRIAL REGISTRATION NUMBER: INPLASY; INPLASY202220099 Lippincott Williams & Wilkins 2022-03-18 /pmc/articles/PMC10684229/ /pubmed/35356947 http://dx.doi.org/10.1097/MD.0000000000029105 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol Systematic Review
Moon, Jeong-Hyun
Sung, Won-Suk
Choi, Seong-Kyeong
Kim, Jung-Hyun
Suh, Jin-woo
Kim, Joo-Hee
Seo, Byung-Kwan
Lee, Seung-Deok
Kim, Eun-Jung
The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title_full The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title_fullStr The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title_full_unstemmed The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title_short The effectiveness and safety of Wu tou decoction on rheumatoid arthritis: A protocol for systematic review and/or meta-analysis
title_sort effectiveness and safety of wu tou decoction on rheumatoid arthritis: a protocol for systematic review and/or meta-analysis
topic Study Protocol Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684229/
https://www.ncbi.nlm.nih.gov/pubmed/35356947
http://dx.doi.org/10.1097/MD.0000000000029105
work_keys_str_mv AT moonjeonghyun theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT sungwonsuk theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT choiseongkyeong theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimjunghyun theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT suhjinwoo theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimjoohee theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT seobyungkwan theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT leeseungdeok theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimeunjung theeffectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT moonjeonghyun effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT sungwonsuk effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT choiseongkyeong effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimjunghyun effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT suhjinwoo effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimjoohee effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT seobyungkwan effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT leeseungdeok effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis
AT kimeunjung effectivenessandsafetyofwutoudecoctiononrheumatoidarthritisaprotocolforsystematicreviewandormetaanalysis